Postdoctoral Associate Position

Laboratory of Joe Zaia, Department of Biochemistry

Center for Biomedical Mass Spectrometry, Boston University

Alzheimer’s disease is the most common cause of dementia and a serious economic burden. While cerebrovascular integrity is essential for brain metabolism, its dysfunction plays a critical role in the pathogenesis of Alzheimer’s disease. The goal of this project is to elucidate the functional interplay between cerebrovascular remodeling and Alzheimer’s disease progression. The hypothesis is that structural and functional alterations in cerebrovasculature is correlated with neurodegeneration. Working in a multidisciplinary team, we are correlating vascular mechanobiology, optical imaging, neuropathology, glycomics and proteomics in an effort to discover new molecular mechanisms and treatment options for Alzheimer’s disease.

We seek a postdoctoral scientist with experience in glycomics and/or proteomics for this project. The project will involve quantitative glycomics and proteomics of cerebrovasculature. The postdoctoral scientist will conduct brain tissue sample preparation and glyco/proteomics LC-MS experiments. S/He will work within a collaborative team including mechanobiologists, biochemists, analytical chemists, bioinformaticians and neuropathologists to develop and validate a statistically rigorous changes to cerebrovascular glyco/protein structure that occur during Alzheimer’s disease progression.

Competitive salary and benefits are available commensurate with experience.  Fluent spoken English, a strong publication track record, and a cooperative attitude are a must for this position.  The Zaia group is part of the Center for Biomedical Mass Spectrometry at Boston University.  This highly collaborative group provides excellent opportunities for career development of a young Ph.D. scientist.

Candidates should have a recent Ph.D. in analytical chemistry, biochemistry, or a related biomedical field with strong experience in biomolecular mass spectrometry.  Glycomics, proteomics and/or glycoproteomics experience is preferred. 

Candidates should send curriculum vitae, cover letter, and contact information for three letters of reference to Joe Zaia ([email protected]).

Boston University prohibits discrimination against any individual on the basis of race, color, religion, sex, age, national origin, physical or mental disability, sexual orientation, gender identity, genetic information, military service, pregnancy or pregnancy-related condition, or because of marital, parental, or veteran status.