Postdoctoral Associate (Congenital Disorders of Glycosylation)
Freeze Lab

Sanford Burnham Prebys is a preeminent, independent biomedical research institute dedicated to understanding human biology and disease, and advancing scientific discoveries to profoundly impact human health.

Dr. Hudson Freeze has a Postdoctoral Associate position available to study the biochemistry and cell biology of a variety of human glycosylation disorders and the opportunity to blend fundamental Glycobiology with medical and translational opportunities. Being part of this lab provides opportunities to have strong interactions with families/patients, physicians, and multiple NIH-sponsored consortia. You will discover, validate, or identify the molecular basis of entirely new disorders of glycosylation. These involve inherited or de novo mutations that affect single or multiple glycosylation pathways. These disorders affect enzyme activity, ER-Golgi protein trafficking and sugar metabolism. Dr. Freeze’s lab uses cells and other models to study these diseases.

The ideal candidate will have first author publications and hands-on experience in areas that may include mammalian cell metabolism, biochemistry, glycobiology, glycan analysis, signaling pathways and gene manipulation. Prior experience in flow cytometry, fluorescense microscopy, proteomics, metabolomics, ER-Golgi interactions, ERAD, and functions of glycosylation will be advantageous.

We seek someone who is independent, self-motivated, with strong critical thinking skills who also thrives in collaborative relationships, builds relationships and is able to effective communication across lab functions.

To learn more about Dr. Freeze's research, please visit: https://sbpdiscovery.org/team/hudson-freeze-phd.

 

• About Dr. Freeze and his research
• N-Glycanase 1 Transcriptionally Regulates Aquaporins Independent of Its Enzymatic Activity
• SLC35A2-CDG: Functional characterization, expanded molecular, clinical, and biochemical phenotypes of 30 unreported Individuals
• A Recurrent De Novo Heterozygous COG4 Substitution Leads to Saul-Wilson Syndrome, Disrupted Vesicular Trafficking, and Altered Proteoglycan Glycosylation
• Perspectives on Glycosylation and Its Congenital Disorders
• Predominant and novel de novo variants in 29 individuals with ALG13 deficiency: Clinical description, biomarker status, biochemical analysis, and treatment suggestions

 

TO APPLY: Interested candidates should apply online by submitting one PDF document with a cover letter, CV, 3 references and list of any publications or accomplishments. In your cover letter, please indicate your specific motivation for this position and favorite paper from the lab.

 

• Independently design and perform experiments and procedures with high degree of complexity, demonstrating increasing expertise with a wide range of techniques
• Demonstrate flexibility in adapting methods and skills according to evolving project priorities
• Provide independent experimental design and planning
• Be able to analyze and interpret data from different sources and draw relevant conclusions
• Demonstrate knowledge in relevant specialized disciplines
• Be able to present results at internal and external meetings
• Accurately document experiments
• Contribute to the writing of reports and manuscripts with increasing responsibility over time

• Ph.D. degree in Science or MD-PhD with strong experience and background in biochemistry and cell biology is required
• Demonstrated first author publications

• The ability to work independently and to handle multiple projects and deadlines
• Demonstrated ability to work in an interactive and collaborative team
• Excellent presentation, verbal, and written communication skills
• Possess strong attention to detail, analytical, time management, organizational, and interpersonal skills
• Embody the Institute's core values of Commitment, Collaboration, Communication, Community and Compassion

 

Sanford Burnham Prebys Medical Discovery Institute is an Equal Opportunity Employer – M/F/Veteran/Disability – committed to the hiring, advancement and fair treatment of all individuals. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, protected veteran status, or any other protected status as designated by federal, state or local law. For additional information about your rights as an applicant.