Res Post Doc Fellow
Dr. Andrew Edmondson
Congenital Disorders of Glycosylation (CDG)

The congenital disorders of glycosylation (CDG) are a group of rare genetic disorders that disrupt the cellular glycosylation machinery. Affected patients exhibit severe neurological deficits. Despite being an essential post-translational modification, the roles of glycosylation in protein function are highly complex and remain poorly understood. The genetic basis of CDG provides an opportunity to identify the neurobiological functions of glycosylation using mouse models and glycoproteomics. In tandem, an understanding of glycosylation in the nervous system will help to elucidate the pathophysiology of CDG, enabling therapeutic advances.

Dr. Andrew Edmondson is an enthusiastic new PI who seeks a postdoctoral fellow to help uncover the molecular mechanisms underlying dysfunctional glycosylation in mouse and cellular models of CDG. The successful candidate will be self-motivated and hard-working, with strong molecular biology skills (Western blot, qPCR, cell culture), as well as prior experience working with mice and an experimental background in glycobiology or neuroscience. The postdoctoral fellow will be responsible for their own research project investigating a specific human genetic disease of dysfunctional glycosylation (i.e., CDG). Work will largely focus on molecular investigations in tissues and cells derived from mice and affected human patients. Transformative discoveries in basic and translational glycobiology are anticipated.

Postdocs will be expected to participate in project planning, recording and interpretation/evaluation of data, and communication of results. Postdocs will also be expected to acquire technical, lab management, and manuscript/grant writing skills; and participate in seminars, lectures, poster sessions and presentations at national meetings.  Postdoctoral fellows also may be required to supervise junior lab members, develop new methods and protocols for research (such as enzymatic assays), and assist with the development of other research projects in the lab.

Interested and qualified individuals should submit their resume on careers.chop.edu and to Andrew Edmondson, MD, PhD ([email protected])

 

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