Res Post Doc Fellow
Dr. Andrew Edmondson
Congenital Disorders of Glycosylation (CDG)

Philadelphia, PA, US, 19104
Location: LOC_ABRAMSON-Abramson Building 
Req ID: 149516
Shift: Days
Employment Status: Regular - Full Time 

Job Summary

The congenital disorders of glycosylation (CDG) are a group of rare genetic disorders that disrupt the cellular glycosylation machinery. Affected patients exhibit severe neurological deficits. Despite being an essential post-translational modification, the roles of glycosylation in protein function are highly complex and remain poorly understood. The genetic basis of CDG provides an opportunity to identify the neurobiological functions of glycosylation using mouse models and glycoproteomics. In tandem, an understanding of glycosylation in the nervous system will help to elucidate the pathophysiology of CDG, enabling therapeutic advances.

Dr. Andrew Edmondson is an enthusiastic new PI who seeks a postdoctoral fellow to help uncover the molecular mechanisms underlying dysfunctional glycosylation in mouse and cellular models of CDG. The successful candidate will be self-motivated and hard-working, with strong molecular biology skills (Western blot, qPCR, cell culture), as well as prior experience working with mice and an experimental background in glycobiology or neuroscience. The postdoctoral fellow will be responsible for their own research project investigating a specific human genetic disease of dysfunctional glycosylation (i.e., CDG). Work will largely focus on molecular investigations in tissues and cells derived from mice and affected human patients. Transformative discoveries in basic and translational glycobiology are anticipated.

Postdocs will be expected to participate in project planning, recording and interpretation/evaluation of data, and communication of results. Postdocs will also be expected to acquire technical, lab management, and manuscript/grant writing skills; and participate in seminars, lectures, poster sessions and presentations at national meetings.  Postdoctoral fellows also may be required to supervise junior lab members, develop new methods and protocols for research (such as enzymatic assays), and assist with the development of other research projects in the lab.

Interested and qualified individuals should submit their resume on and to Andrew Edmondson, MD, PhD ([email protected])
Job Responsibilities
  1. Conduct independent scholarly research and develop new methods and protocols
  2. Participate in project planning, recording and evaluation of data
  3. Acquire technical, lab management and grant writing skills
  4. Participate in seminars, lectures, poster sessions and presentation at national meetings
  5. Supervise junior lab members
  6. Assist with other research projects
Required Education and Experience
  • A terminal degree PhD, MD, DVM, etc.
  • According to the CMS (Centers for Medicaid and Medicare Services) a copy of diploma or transcript is required as proof of academic achievement.
Additional Technical Requirements
All CHOP employees who work in a patient building or who provide patient care are required to receive an annual influenza vaccine unless they are granted a medical or religious exemption.
Children's Hospital of Philadelphia is committed to providing a safe and healthy environment for its patients, family members, visitors and employees. In an effort to achieve this goal, employment at Children's Hospital of Philadelphia, other than for positions with regularly scheduled hours in New Jersey, is contingent upon an attestation that the job applicant does not use tobacco products.
Children's Hospital of Philadelphia is an equal opportunity employer. We do not discriminate on the basis of race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability or protected veteran status.
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CHOP Careers Contact 
Talent Acquisition
2716 South Street, 6th Floor
Philadelphia, PA 19146 

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posted November 22, 2021