Title:  Sci II / Senior Scientist – Tumor glycobiology, Target Biochemistry

Hiring Manager:  Philippe Marguet

Who we are
Atreca is an integrated biotechnology company located in a brand-new campus in San Carlos, CA. We apply our proprietary drug discovery platform to profile clinically relevant, active B cell responses in patients receiving successful treatment and, in turn, develop a portfolio of antibody therapeutics against novel tumor targets with the potential to treat large patient populations. Atreca seeks talented, driven individuals who are dedicated to making a positive impact on human health and are motivated to become key members of a growing company.

Position Summary
We are seeking an outstanding and highly motivated scientist to join our Target Biochemistry group and become a key member of the research team. Target Biochemistry identities targets as well as elucidates the molecular-level interactions involving Atreca’s patient-derived antibodies and their disease-associated antigens. This role focuses on tumor associated carbohydrate antigens (TACAs) and is a fantastic and high-visibility opportunity to develop an emerging class of cancer therapeutics at Atreca. If you are an enthusiastic multidisciplinary scientist, consider applying to this exciting position!

Duties and Responsibilities

  • Expand an experimental pipeline that identifies the binding properties exhibited by members of Atreca’s collection of glycan-dependent, tumor-specific, antibodies. Lead operations ranging from screening antibody collections to structure-level investigations of high-interest candidates
  • Demonstrate subject matter expertise in the field of tumor-associated carbohydrate antigens and provide insights into strategic approaches for successful drug development
  • Investigate and determine the nature of glycan-decorated cellular targets (protein classes or features, glycolipids, etc.)
  • Support sourcing and generation of high-purity target material reflecting the cancer glycan presentation
  • Collaborate cross-functionally with internal teams for the selection, engineering, and evaluation of therapeutics leveraging aberrant glycosylation for cancer selectivity (ADCs, bispecifics, etc.)
  • Manage academic research collaborations and vendor relationships
  • Document and communicate results in a comprehensive, clear, and accurate manner
  • Lead from the bench, potential for one SRA report
  • Follow laboratory safety guidelines and practices

Required Skills and Qualifications

  • PhD in Immunology, Biochemistry, Chemical Biology, or a related field plus 2 years relevant experience
  • Master’s in Immunology, Biochemistry, Chemical Biology, or a related field plus 5 years relevant experience
  • Experience developing and applying protocols for glycan identification (ex. Chemoenzymatic glycan synthesis, mass spec glycoproteomics, glycan arrays, glycoengineering cell lines, HPLC/UPLC, etc.)
  • Experience in tumor-specific glycobiology preferred
  • Experience with characterization of antibody / glycan complexes preferred
  • Experience with Antibody / Antigen binding and affinity techniques (Immunoprecipitation, ELISA, Western, Biacore, Octet,  etc.) preferred
  • Strong analytical skills, excellent communication skills, and attention to detail
  • Track record of being innovative, adaptable, and scientifically rigorous
  • Ability to work in a team, prioritize tasks, and drive projects to completion

Apply on LinkedIn or at https://www.atreca.com/careers/ (note: accept cookies for proper rendering)

Exact title commensurate with experience. Atreca is an equal opportunity employer.

posted: March 13, 2023