Glycobiology at the Forefront of Human Health and Disease

Schedule of Events
(as of 10/19/21)

Sunday, November 7

9:00 am–5:00 pm        Satellite: NCFG/CFG-Tools in Glycoscience​ & Glyco in Biotechnology  ($50 fee)

9:00 am–3:00 pm        Trainee Mentoring Program ($50 fee)

3:15 pm–5:00 pm        Board of Directors Meeting (by invitation only)

4:30 pm–9:30 pm        Registration Opens

5:30 pm–7:30 pm        Conference Opening Remarks
                                         Nancy Dahms, SFG President
                                         Medical College of Wisconsin

                                         Session 1: Meyer and Kornfeld Awards Lectures
                                         Karl Meyer Lectureship Award
                                         John Hanover - NIH National Institute of Diabetes & Digestive and Kidney Diseases

                                         Rosalind Kornfeld Award for Lifetime Achievement in Glycobiology
                                         Linda  Baum - University of California Los Angeles
                                         Michael Pierce - University of Georgia/CCRC

7:30 pm–9:30 pm.      Welcome Reception


Monday, November 8

7:30 am–6:30 pm        Registration Open

7:30 am–8:30 am        Continental Breakfast

8:30 am–10:00 am     Session 2: Biomes and Host-Microbe Interactions
                                       Mario Feldman (Chair), Washington University, St. Louis

                                       Keynote Speakers:
                                       Alisdair Boraston, University of Victoria, British Columbia
                                       Architectural sophistication contributes to substrate recognition by 
                                       O-glycopeptidases

                                       Mario Feldman, Washington University, St. Louis
                                          Bacterial Vesicles and the Degradation of Complex Glycans in the Human Gut

                                       Samantha King, The Ohio State University
                                       Novel Strategies Employed by Streptococcito Bind Host Glycans

                                       Poster Talks:
                                       Diego Sastre (Emory University School of Medicine) - Structural and molecular
                                       analysis of endoglycosidases and SusD-like proteins reveal a possible cooperation
                                       for the import of N-glycans in the gut microbiome

                                       Robert Woods (Complex Carbohydrate Research Center) - The role of spike protein
                                       glycosylation in modulating SARS-CoV-2 antigenicity and adhesion

                                        Ieva Bagdonaite (Copenhagen Center for Glycomics) - Probing the Functions of
                                        Glycosylation in Herpesvirus Biology Using a Glycoengineered Cell Library

10:00 am–10:20 am   Break

10:20 am–12:20 pm   Session 3: Glycans and Cancer
                                       Susan Bellis (Chair), University of Alabama Birmingham

                                       Keynote Speakers:
                                       Gabriela Chiosis, Memorial Sloan Kettering Cancer Center 
                                       On how N-glycosylation turns a chaperone into pathologic epichaperome structures

                                       Susan Bellis, University of Alabama Birmingham
                                       Receptor Sialylation by ST6GAL1 Promotes Pancreatic Cancer Development &
                                       Progression

                                       Valerie Weaver, University of California San Francisco, Force, Glycans and Tumor
                                       Aggression

                                       Avery Posey Jr., University of Pennsylvania
                                       Engineering T cells to target Tn-glycopeptides on the tumor surface and in the
                                       extracellular matrix


                                       Poster Talks:
                                       Simon Wisnovsky (University of British Columbia) - Genome-Wide CRISPR Screens
                                       Reveal Specific Ligands for Glycan-Binding Immune Checkpoint Receptors

                                       Hector Cuello (University of California San Diego) - Is Siglec-XII functionally
                                       significant in aggressive carcinomas?  

                                       Asmi Chakraborty (Florida International University) - Hypoxia controls the
                                       glycobiological signature and  related pro-tumorigenic properties of metastatic
                                       melanomas

                                       Sharon Yehuda (Tel Aviv University) - Klotho: a tumor suppressor with a potential
                                       glycosidase activity

12:20 pm–1:30 pm    Lunch on your own

1:30 pm–4:00 pm       Poster Session 1 and Exhibits

4:00 pm–5:50 pm       Session 4: Neuroglycobiology
                                       Linda Hsieh-Wilson (Chair), California Institute of Technology

                                       Keynote Speakers:
                                       Matthew Pratt, University of Southern California
                                       O-GlcNAc Activates Small Heat Shock Proteins to Block Amyloid Aggregation 

                                       Linda Hsieh-Wilson, California Institute of Technology
                                       Chondroitin 4-O-sulfation regulates hippocampal perineuronal nets and synaptic
                                       plasticity

                                        Richard Cummings, Harvard Medical School, Glycobiology of the Brain and in
                                        Schizophrenia

                                        Peng Zhang, Case Western Reserve University School of Medicine       
                                        Sweet at synapses: the role of heparan sulfate on neurexin1 in synapse organization

                                       Poster Talks:
                                       
Melissa Koff (Texas A&M University) - TMTC-type O-mannosyltransferases as
                                       potential regulators of cadherin functions in Drosophila 

                                       Sajina GC (University of Alabama at Birmingham)ST6Gal1-Mediated Silalylation
                                       Promotes Brain Tumor Initiating Cell Maintenance

                                       Andrew Edmondson (Children's Hospital of Philadelphia) - Modeling neurological
                                       aspects of GALNT2-CDG in mice


5:50 pm–6:30 pm       Session 5: Innovator and Service Awards

                                       President’s Innovator Award 
                                       Suzanne Walker
- Harvard Medical School

                                       Distinguished Service Award
                                       Pamela Marino - Kelly Government Solutions


Tuesday, November 9

7:30 am–6:15 pm        Registration Open

7:30 am–8:30 am        Continental Breakfast

8:30 am–10:00 am      Session 6: Glycans and Infectious Disease
                                        Karin Hoffmeister (Chair)Versiti Blood Research Institute

                                        Keynote Speakers:
                                        Fikri Avci, University of Georgia/CCRC 
                                        Immune Interactions of viral surface glycoproteins

                                        Christopher Barnes, Stanford University
                                        Structural insights into antibody-mediated neutralization of SARS-CoV-2

                                        Elisa Fadda, Maynooth University
                                        Fine-tuning the Spike: Role of the nature and topology of the glycan shield in the
                                        structure and dynamics of the SARS-CoV-2 S

                                       Poster Talks:
                                       Gloria Polanco (Washington University School of Medicine) - Knockout of
                                       Mitochondrial Fucosyltransferase FUT1 or Golgi Nucleotide Sugar Transporter LPG2
                                       Leads to Significant Changes in the L. major Proteome 

                                      Jitske van Ede (Delft University of Technology) - Revealing the physicochemical
                                      dynamics in Campylobacter jejuni flagellum sialylation

                                      John Magnani (GlycoMimetics, Inc.) - Early Treatment of Sickle Cell Disease Patients
                                      in Vaso-Occlusive Crisis with Glycomimetic Selectin Antagonist, Rivipansel Achieves
                                      Earlier Discontinuation of IV Opioids and Shorter Hospital Stay. Post Hoc Analysis
                                      of the RESET Trial

10:00 am–10:20 am Break        

10:20 am–12:20 pm Session 7: Glycans in Immune Homeostasis and Inflammation
                                     Stephanie Olivier-Van Stichelen (Chair), Medical College of Wisconsin

                                     Keynote Speakers:
                                     Jarrod W Barnes, University of Alabama Birmingham, Targeting Glycans As
                                     Novel Treatment Strategies for Chronic Inflammatory Airway Disease

                                     Michael Demetriou, University of California Irvine
                                     Regulation of T cells, B cells, myelination, multiple sclerosis and immune senescence
                                     by N-glycan branching and N-acetylglucosamine

                                     Salomé Pinho, University of Porto
                                     A Bitter Sweet Symphony in Immune response: glycans as key checkpoints in
                                     autoimmunity and cancer

                                     Galit Alter, Ragon Institute of MGH, MIT, and Harvard
                                     Vaccine mediated antibody-glycosylation tracks with protection against respiratory
                                     pathogens

                                     Poster Talks:
                                     Alejandro  Cagnoni (Institute of Biology and Experimental Medicine)
                                     Targeting Galectin-1 Unleashes Antitumor Response in Colitis-Associated
                                     Colorectal Cancer by Shaping the CD8+ Regulatory Cell Compartment

                                     Jan Novak (University of Alabama Birmingham)
                                   
  Experimental evidence of the pathogenic potential of aberrantly O-glycosylated IgA1,
                                     the main autoantigen in IgA nephropathy
 

                                     Inês Alves (Institute for Research and Innovation in Health)
                                     Protein mannosylation as a diagnostic and prognostic biomarker of lupus nephritis: an
                                     unusual glycan-
neoepitope in Systemic Lupus Erythematosus

                                    Leandre Glendenning (Case Western Reserve University)
                                    IgG poorly localizes to the trans-Golgi network of antibody-producing B cells

12:30 pm–1:30 pm  Lunch on your own

1:30 pm–4:00 pm    Poster Session 2 and Exhibits

4:15 pm–5:00 pm     SFG Business Meeting

5:00 pm–6:15 pm    Session 8: MCP/ASBMB & Glycobiology Significant Achievement Awards

                                    Molecular & Cellular Proteomics (MCP)/American Society for Biochemistry and
                                    Molecular Biology (ASBMB) Lectureship Award
                                    
Joseph Zaia - Boston University School of Medicine

                                    Glycobiology Significant Achievement Award
                                    
Peng Wu - Scripps Research Institute

7:00 pm–11:00 pm Banquet Dinner


Wednesday, November 10

7:00 am–2:50 pm.  Registration Open

7:00 am–8:00 am   Continental Breakfast

8:00 am–9:40 am   Session 9: From Glycans to Glycoproteomics
                                   Michael Tiemeyer (Chair), University of Georgia/CCRC

                                   Keynote Speakers:
                                   Ryan FlynnBoston Children’s Hospital/Harvard University
                                   Small RNAs are modified with N-glycans and displayed on the surface of living cells

                                   Morten Thaysen-Andersen, 
Macquarie University
                                   Dynamic paucimannosidic protein formation via a non-canonical truncation pathway in
                                   human neutrophils

                                   Kay-Hooi Khoo, Academia Sinica
                                   Discovery and precision mapping of various fucosylated, sialylated and sulfated
                                   glycotopes at glycomic level

                                   Poster Talks:
                                 
 Noortje de Haan (University of Copenhagen) - Combining a non-reductive O-glycan
                                   release method with glyogenomics enables the in-depth O-glycan profiling of human
                                   tissues by C18 LC-MS

                                    Nicholas Riley (Stanford University) -  Real-time selection of glycopeptide dissociation
                                    methods by matching oxonium patterns using a real-time library search

                                    Martin Pabst (Delft University of Technology) - A multidimensional glycoproteomics
                                    approach to explore prokaryotic protein glycosylation

                                    Richard Drake (Medical University of South Carolina) - Linking carbohydrate tumor
                                    antigen immunohistochemistry with N-glycan imaging mass spectrometry and
                                    targeted glycoproteomics on the same tumor slide

9:40 am–10:00 am Break

10:00 am–12:00 pm Session 10: Glycoengineering and Applied Glycobiology
                                     Stacy Malaker (Chair), Yale University 

                                     Keynote Speakers:
                                     Daniel Bojar, University of Gothenburg
                                        Endless Forms Most Beautiful – Merging Machine Learning and Glycobiology

                                     Stacy Malaker, Yale University
                                     Revealing the human muncinome

                                     Yvette van Kooyk, Amsterdam University Medical Center
                                     Glycocode of the tumormicroenvironment  a novel immune check-point

                                     Yoshiki Narimatsu, University of Copenhagen
                                     Genetic glycoengineering in mammalian cells

                                     Poster Talks:
                                     Mia Huang (Scripps Research) - Mapping glycosylation-dependent changes in
                                     glycoprotein ligandability across the proteome

                                     Gao-Lan Zhang (Johns Hopkins University) - Ganglioside interactome targeting with
                                     clickable photoaffinity bifunctional ganglioside probes

                                     Han Wu (University of Texas Southwestern Medical Center) - Characterization of
                                     glycan-dependent interactions in cells by metabolic labeling using photocrosslinking
                                     GlcNAc and GalNAc analogs

                                     Michael Mannino (University of Georgia) - The Application of Optogenetics to OGT
                                     Targeting in Mammalian Cells

12:00 pm–1:00 pm   Lunch on your own

1:00 pm–2:50 pm      Session 11: Disorders of Glycan Synthesis and Degradation
                                      Hudson Freeze (Chair), SBP Medical Discovery Institute

                                      Keynote Speakers:
                                      Richard Steet, Greenwood Genetic Center
                                      Cathepsin-mediated pathogenesis of lysosomal disease

                                      Ethan Perlstein, Perlara
                                      Aldose reductase inhibition targets the root causes of PMM2-CDG

                                      Poster Talks:
                                  
    Paulina Sosicka (Sanford Burnham Prebys Medical Discovery Institute) - Multiple,
                                     distinct, cytoplasmic pools of GDP-fucose target different fucosyltransferases

                                     Jeff SoRelle (University of Texas Southwestern Medical Center) - A Murine Mpi
                                     mutation reproduces aspects of Human Congenital Disorder of Glycosylation Type 1B


                                     Keynote Speaker:
                                     Clement Chow, University of Utah School of Medicine
                                     
A CRISPR Screen for Modifiers of the Rare Disease DPAGT1-CDG (CDG-Ij)

                                     Poster Talk:
                                     Vladimir Lupashin (University of Arkansas for Medical Sciences) - Novel cellular
                                     models for COG complex-related CDG-II diseases

                                     Keynote Speaker:
                                     
Hudson Freeze, SBP Medical Discovery Institute
                                       A Single Mutation in COG4 Causes Saul Wilson Syndrome: Exploring Causes and
                                      Consequences

2:50 pm–3:00 pm
    Conference Closing Remarks

                                      Nancy Dahms, SFG President
                                      Medical College of Wisconsin