April 29, 2016

New job post: Postdoctoral Associate position at the Sanford Burnham Prebys Medical Discovery Institute (SBP) (La Jolla, CA)

Postdoctoral Associate position at the Sanford Burnham Prebys Medical Discovery Institute (SBP) (La Jolla, CA)
Contact: Dr. Hudson Freeze; azimmon@sbpdiscovery.org.

Description:
A postdoctoral position is immediately available at the Sanford Burnham Prebys Medical Discovery Institute (SBP) to study NGLY1 mutations that cause a recently discovered human neurological disease of protein N-de-glycosylation. The pathological mechanism is unknown. 
 
Our team combines cell biology, biochemistry, and human genetics in solve Congenital Disorders of Glycosylation (CDG) including NGLY1. Fundamental discoveries are aimed at translational applications that can benefit patients. 
 
The postdoc will drive the project to identify consequences of disrupted N-glycan cleavage from misfolded glycoproteins that are retro-translocated into the cytoplasm. Plans include a search for obligate substrates, alternate cleavage pathways, potential therapeutic molecules, and analysis of patient cells. Techniques include gene manipulation, glycan analysis, fluorescence methods, and proteomic analysis.

Close collaborations with other NGLY1 research laboratories, the NIH, and philanthropic organizations provide unique interactive opportunities for the candidate.
 
If interested in this challenging research opportunity in NGLY1, please read PMID: 24651605, PMID: 25900930, and http://www.newyorker.com/magazine/2014/07/21/one-of-a-kind-2
 
Required Skills:
        Recent PhD or MD/PhD with strong motivation and background in biochemistry, genetics, cellular & molecular biology.
        First-author publications in any 2 of the following: biochemistry, cell biology, glycobiology, gene manipulation, ERAD or cytoplasmic protein degradation.
        Excellent verbal/written communication skills in fluent English.
        Previous experience in a biochemistry, genetics, or cellular/molecular biology lab based in the United States. 
        Independent self-starter who thrives in a highly interactive, collaborative scientific environment.
 
How to Apply:
Send a single PDF document that includes all of the following:
        Your current CV
        1 page letter outlining your background, specific interest in NGLY1, and how you would like to study it.
        3 recent reference contacts for this project.
 
Email the PDF document to Dr. Hudson Freeze at azimmon@sbpdiscovery.org.



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