April 27, 2016

New job post: NIH-supported postdoctoral position: Regulation of Immunity and Glycosylation In The Endoplasmic Reticulum (Dallas, TX)

Posted: April 27, 2016
NIH-supported postdoctoral position: Regulation of Immunity and Glycosylation In The Endoplasmic Reticulum (Dallas, TX)

Description:
An NIH-supported postdoctoral position is available in a collaboration between Dr. Mark Lehrman, Department of Pharmacology, and Dr. Nan Yan, Departments of Immunology and Microbiology, UT Southwestern Medical Center at Dallas.  The collaboration focuses on TREX1/DNaseIII, an endoplasmic reticulum-associated exonuclease that regulates autoimmunity.  TREX1 defects account for several human disorders.  We recently found that TREX1 controls oligosaccharyltransferase function in a disease-specific manner (Hasan et al. (2015) Immunity 43:463-474).  Projects include examination of TREX1-dependent immunogenic free glycans, and proteomic identification of underglycosylated antigenic epitopes exposed by TREX1 dysfunction.  Explorations of other aspects of glycosylation and immunity are also being developed.  The work is driven by availability of rigorous biochemical and genetic glycobiological approaches, patient-derived cells, and mouse models of TREX1 disorders. Please see:


Candidates must hold a Ph.D. or comparable degree, with experience in glycobiology, immunology, microbiology, or biochemistry.  Interested individuals should send a CV, statement of interests, and a list of three references to:

Mark Lehrman, Ph.D.
Professor, Department of Pharmacology
UT Southwestern Medical Center
6001 Forest Park Rd. 
Dallas, TX 75390-9041

UT Southwestern is an Equal Opportunity, Affirmative Action Employer


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