November 20, 2015

New job posting: Post Doctoral Researcher/Research Fellow - 3Yr post, University of Nottingham, UK

Post Doctoral Researcher/Research Fellow - 3Yr post, University of Nottingham, UK (Cathy Merry's Group)
Contact: Dr Cathy Merry, tel 0115 8231234 or email cathy.merry@nottingham.ac.uk


This post will recruit a talented, proactive postdoctoral researcher to work on an exciting interdisciplinary, translational project funded by the National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs). The project will combine cancer cell biology, matrix biology, glycobiology, proteomics and biomaterials science to address a workplan entitled: "A multi-cellular 3D model of human breast tissue to replace rodent xenograft models in breast cancer research".

This post will be based in Nottingham but will collaborate extensively within the collaborative group, which includes Dr. Gillian Farnie and Prof. Tony Howell from the Institute of Cancer Sciences and the Christie Hospital in Manchester. This project will develop a bespoke non-animal based in vitro system that better replicates the tissue specific environment experienced by human breast and breast cancer cells, creating model systems that are then suitable for use in diagnostics and drug screening as well as improving our understanding of the interactions of breast cancer cells with their local environment. We intend to focus initial development of this breast tissue model on the pre-invasive breast cancer, ductal carcinoma in situ (DCIS), characterised by proliferation of malignant epithelial cells to fill the breast duct but separated from the stroma by an intact basement membrane and a layer of myoepithelial cells. If left untreated, progression to invasive cancer is observed in 30-50% of patients creating a clinical challenge to identify which patients do not require further treatment. Therefore, DCIS can be viewed as a temporary hiatus in malignant development, offering an opportunity for researchers to determine the key factors in the cellular microenvironment permitting invasive progression and providing an ideal test environment for our 3D model to be built upon.

The successful candidate will combine excellence in research, collaboration, communication and meeting deadlines with knowledge of one or more of these areas, including: experience of using hydrogels or other 3D cell culture environments and / or cancer cell biology; glycobiology (specifically glycosaminoglycans) and proteomics, particularly of matrix proteins; multicellular culture systems / cell characterisation including molecular biology skills and high quality imaging.

This full time post will be offered on a fixed-term contract for 3 years, with anticipated start date of Jan 2016.
Informal enquiries may be addressed to Dr Cathy Merry, tel 0115 8231234 or email cathy.merry@nottingham.ac.uk.


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