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Posted September 15, 2015
Postdoctoral Research Associate, Structural Glycomics and Proteomics at the University of Mississippi School of Pharmacy
Contact:  Prof. Joshua Sharp, Ph.D.

The University of Mississippi School of Pharmacy, Department of BioMolecular Sciences is searching for a Postdoctoral Research Associate in the field of Structural Glycomics and Proteomics for a position currently open.  The successful candidate will join an active NIH-funded research program coupling protein and carbohydrate chemistry with mass spectrometry to study the structure and function of carbohydrates (specifically, glycosaminoglycans) and proteins, as well as understand the interactions between the molecules.  Opportunities to participate in multiple projects are available, including studies involving HIV-antibody interactions, the molecular function of chemokines and their role in cellular trafficking, and the structural determinants governing glycosaminoglycan-mediated cell-cell communication.  Active projects in software development are also ongoing, and available for participation.  The laboratory currently houses a new Thermo Orbitrap Fusion mass spectrometer coupled to a Dionex nanoUltimate 3000 UPLC, and several other mass spectrometers are available through the School of Pharmacy.  
The University of Mississippi is located in Oxford, MS, which is commonly rated among the top college towns in the country.  The School of Pharmacy is ranked in the top ten nationally for research funding, and is home to the National Center for Natural Products Research.  Interested candidates are asked to send a cover letter, CV, and arrange for at least three letters of reference to be sent to Prof. Joshua Sharp (  Review of applications will begin immediately, and continue until the position is filled.

The University of Mississippi provides equal opportunity in any employment practice, education program, or education activity to all qualified persons. The University complies with all applicable laws regarding equal opportunity and affirmative action and does not unlawfully discriminate against any employee or applicant for employment based upon race, color, gender, sex, sexual orientation, gender identity or expression, religion, national origin, age, disability, veteran status, or genetic information.

A Ph.D. in Chemistry, Biochemistry, Pharmacology or a related field is required; Ph.D. students nearing the end of their studies with an anticipated date of degree completion prior to January 1, 2016 are also encouraged to apply.  A strong research background with multiple quality publications is required. 

Interested candidates are asked to send a cover letter, CV, and arrange for at least three letters of reference to be sent by email to: 

Joshua Sharp, Ph.D. 
Assistant Professor, Department of BioMolecular Sciences
University of Mississippi School of Pharmacy
PO Box 1848
University, MS 38677-1848

Posted September 10, 2015
Regulation of Immunity and Endoplasmic Reticulum Glycosylation By TREX1/DNaseIII

An NIH-supported postdoctoral position is available in a collaboration between the laboratories of Dr. Mark Lehrman, Department of Pharmacology, and Dr. Nan Yan, Departments of Medicine and Microbiology, UT Southwestern Medical Center at Dallas.  TREX1/DNaseIII is an endoplasmic reticulum-associated exonuclease that regulates autoimmunity, and point mutations in its gene are responsible for several human disorders.  Remarkably, TREX1 also controls oligosaccharyltransferase function in a disease-specific manner (Hasan et al. (2015) "Cytosolic Nuclease TREX1 Regulates Oligosaccharyltransferase Activity Independent of Nuclease Activity to Suppress Immune Activation", Immunity, in press - DOI:  Projects include discovery of novel oligosaccharyltransferase-dependent immunogenic free glycans, and proteomic identification of underglycosylated antigenic epitopes exposed by TREX1 dysfunction.   Please see:

Candidates must hold a Ph.D. or comparable degree, with experience in glycobiology, immunology, microbiology, or biochemistry.  Interested individuals should send a CV, statement of interests, and a list of three references to:

Mark Lehrman, Ph.D.
Professor, Department of Pharmacology
UT Southwestern Medical Center
6001 Forest Park Rd. 
Dallas, TX 75390-9041

UT Southwestern is an Equal Opportunity, Affirmative Action Employer

Posted September 8. 2015
Postdoctoral position at the Mount Sinai Hospital in Toronto with Dr. Jim Dennis

Dr. Jim Dennis at the Lunenfeld-Tanenbaum Research Institute in Toronto is seeking a recent PhD graduate with experience in Molecular Biology and an interest in protein glycosylation and regulatory networks. A broad expertise with recombinant techniques used in cell culture and/or animals is required, as well as a familiarity with bioinformatics. We are studying the interaction between specific metabolic pathways in cancer cells, using the CRISPR/CAS9 system for site-directed gene editing in an attempt to suppress growth in a cancer-specific manner. Pathways of interest include the role of protein N-glycosylation feedback regulation of central metabolism though modifications to nutrient transporters and membrane receptors that support growth and survival of cancer cells. In addition to cell lines, we have murine models, and access to clinical samples from cancer, autoimmune and diabetes patients. We have in-house mass spectrometry expertise, and the project will involve targeted (MRM) metabolomics using ABI 5500 system, and an Agilent 6550 Q-TOF for peptide, glycopeptide and N-glycan analysis. The successful candidate will be highly motivated, comfortable with technical challenges and problem solving. Fluent English, a track record of strong publications, and a cooperative attitude are a must for this position. Please submit your CV, statement of current interests and references online

Posted August 6, 2015
Sr Scientist II, Glycobiology for BioMarin, San Rafael, CA

BioMarin leads the biotechnology industry in delivering therapies for chronic and degenerative genetic conditions that reduce patients' quality of life and shorten life spans. We target diseases that lack effective therapies and affect relatively small numbers of patients, many of whom are children. BioMarin will continue to focus on advancing therapies that are the first or best of their kind and make a big difference in improving patients' lives.

We are seeking a Senior Scientist II specialized in preclinical drug discovery with a background in glycobiology to join our growing Drug Discovery team at BioMarin Pharmaceutical, Inc.  The candidate will work in a team environment to identify and evaluate new project ideas and lead the development of small molecule drug discovery programs.   Knowledge of the field of glycobiology is highly desired.  The successful candidate will be responsible for managing internal scientist in addition to managing external contract research labs. 

      Independently leading small molecule drug discovery and development programs
      Guiding the design, development, and use of novel biochemical and cellular assays to support drug development programs
      Communicating project status and risks to peers and management
      Independently identifying innovative drug discovery opportunities
      Collaboration with other functional areas at BioMarin
      Managing internal scientist
      Managing external contract research organizations
      Working in a team environment
      Evaluation of drug discovery opportunities

EXPERIENCE  /  Required Skills:
Candidates need to have at least 8 years of industry drug discovery or development experience.
      Broad knowledge and understanding of small molecule drug discovery and development
      Hands-on experience with biochemical assay development and use in drug development
      Familiarity with bio-analytical tools (HPLC/UPLC, Mass Spec, ELISA)
      Experience working with contract research organizations
      Capable of working independently, yet willing to contribute in a team environment
      Excellent communication skills are essential
      Well organized

Desired Skills:
The ideal candidate will have >10 years of relevant industry drug discovery and development experience.
      Expertise in the field of glycobiology
      Hands-on experience with cell-based assay development and use in drug development

Ph.D. in a biochemistry related field with at least 8 years of small molecule drug discovery experience in an industry setting.  Knowledge of the field of glycobiology.
Job title will be based on education/work experience.

A wide range of modern cell biology, biochemical, and analytical instrumentation will be available.

The successful candidate will interact with a wide range of internal colleagues - including scientists and management.  The candidate will be required to represent the preclinical programs internally and externally.  The position includes significant interactions with external contract research organizations.

This position will manage a small team of research associates and scientists in addition to external contract scientists.

The candidate will be considered for promotion upon consistent demonstration of independent project leadership including the identification of new projects and progressing projects through preclinical research.  Innovation, problem solving, and  communication  will be  important  parts of this. 

The employee may frequently be required to sit and talk or hear.  The employee is occasionally required to stand; walk; use hands to finger, handle, or feel; reach with hands and arms; climb or balance; stoop, kneel, crouch, or crawl and taste or smell.  The employee must occasionally lift and/or move up to 25 pounds.  Specific vision abilities by this job include close vision, depth perception and ability to adjust focus.
BioMarin is an equal opportunity employer

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