Jobs

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Posted August 6, 2015
Sr Scientist II, Glycobiology for BioMarin, San Rafael, CA

Description:
BioMarin leads the biotechnology industry in delivering therapies for chronic and degenerative genetic conditions that reduce patients' quality of life and shorten life spans. We target diseases that lack effective therapies and affect relatively small numbers of patients, many of whom are children. BioMarin will continue to focus on advancing therapies that are the first or best of their kind and make a big difference in improving patients' lives.

We are seeking a Senior Scientist II specialized in preclinical drug discovery with a background in glycobiology to join our growing Drug Discovery team at BioMarin Pharmaceutical, Inc.  The candidate will work in a team environment to identify and evaluate new project ideas and lead the development of small molecule drug discovery programs.   Knowledge of the field of glycobiology is highly desired.  The successful candidate will be responsible for managing internal scientist in addition to managing external contract research labs. 

RESPONSIBILITIES
      Independently leading small molecule drug discovery and development programs
      Guiding the design, development, and use of novel biochemical and cellular assays to support drug development programs
      Communicating project status and risks to peers and management
      Independently identifying innovative drug discovery opportunities
      Collaboration with other functional areas at BioMarin
      Managing internal scientist
      Managing external contract research organizations
      Working in a team environment
      Evaluation of drug discovery opportunities

EXPERIENCE  /  Required Skills:
Candidates need to have at least 8 years of industry drug discovery or development experience.
      Broad knowledge and understanding of small molecule drug discovery and development
      Hands-on experience with biochemical assay development and use in drug development
      Familiarity with bio-analytical tools (HPLC/UPLC, Mass Spec, ELISA)
      Experience working with contract research organizations
      Capable of working independently, yet willing to contribute in a team environment
      Excellent communication skills are essential
      Well organized
      Self-motivated

Desired Skills:
The ideal candidate will have >10 years of relevant industry drug discovery and development experience.
      Expertise in the field of glycobiology
      Hands-on experience with cell-based assay development and use in drug development

EDUCATION
Ph.D. in a biochemistry related field with at least 8 years of small molecule drug discovery experience in an industry setting.  Knowledge of the field of glycobiology.
Job title will be based on education/work experience.

EQUIPMENT
A wide range of modern cell biology, biochemical, and analytical instrumentation will be available.

CONTACTS
The successful candidate will interact with a wide range of internal colleagues - including scientists and management.  The candidate will be required to represent the preclinical programs internally and externally.  The position includes significant interactions with external contract research organizations.

SUPERVISOR RESPONSIBILITY
This position will manage a small team of research associates and scientists in addition to external contract scientists.

CAREER DEVELOPMENT
The candidate will be considered for promotion upon consistent demonstration of independent project leadership including the identification of new projects and progressing projects through preclinical research.  Innovation, problem solving, and  communication  will be  important  parts of this. 

WORK ENVIRONMENT/PHYSICAL DEMANDS
The employee may frequently be required to sit and talk or hear.  The employee is occasionally required to stand; walk; use hands to finger, handle, or feel; reach with hands and arms; climb or balance; stoop, kneel, crouch, or crawl and taste or smell.  The employee must occasionally lift and/or move up to 25 pounds.  Specific vision abilities by this job include close vision, depth perception and ability to adjust focus.
 
BioMarin is an equal opportunity employer


Posted July 9, 2015
The Bertrand Might Postdoctoral Fellowship 
Contact:
 Amy Zimmon; azimmon@sbpdicovery.org

Description: 
The Freeze Lab at Sanford-Burnham-Prebys Medical Discovery Institute is seeking applicants for an immediate postdoctoral opening in the lab.

NGLY1 mutations cause a rare human neurological disease of protein deglycosylation. Protein misfolding, ER-associated degradation, and other metabolic and developmental pathways are likely to be involved in the etiology of this disorder; however, the pathological mechanisms remain largely unknown.

This challenging and rewarding postdoctoral research opportunity is focused on determining the mechanisms of NGLY1 action and defining the cellular responses that occur when NGLY1 function is diminished or lost. The fellowship is funded by the NGLY1 Foundation (www.NGLY1.org) for work in laboratory of Dr. Hudson Freeze in La Jolla, CA.  

Requirements include significant publications in biochemistry, cell biology, glycobiology, ERAD or cytoplasmic protein degradation. Fluent spoken and written English, creative independent thinking, and team spirit are essential.
Please send a single PDF that includes your current CV; a 1 page letter about your background and specific interest in NGLY1 and 3 reference contacts.

For further information on NGLY1 please see:
Enns GM, Shashi V, Bainbridge M, Gambello MJ, Zahir FR, Bast T, et al. Mutations in NGLY1 c ause an inherited disorder of the endoplasmic reticulum-associated degradation pathway. Genet Med Off J Am Coll Med Genet. 2014;16: 751758. 

Ping He, Jeff E Grotzke, Bobby G Ng, Murat Gunel, Hamed Jafar-Nejad, Peter Cresswell, Gregory M Enns, and Hudson H Freeze. A congenital disorder of deglycosylation: Biochemical characterization of N-glycanase 1 deficiency in patient fibroblasts Glycobiology 2015 25: 836-844
"One of a Kind" by Seth Mnookin, The New Yorker, July 2014. http://www.newyorker.com/magazine/2014/07/21/one-of-a-kind-2 . 

Please submit application materials by September 1, 2015 to:  Amy Zimmon azimmon@sbpdicovery.org or to Hudson Freeze, Hudson@sbpdiscovery.org


Posted June 22, 2015
Lab Manager and Research Scientist for GlycoBac, LLC
Contact:
 dljarvis@uwyo.edu

Description: 
Dr. Don Jarvis is seeking a motivated individual to serve in a dual capacity as the Lab Manager and Research Scientist for GlycoBac, LLC  (http://www.glycobac.com/), a new biotechnology company. This position will potentially involve a split appointment, with overlapping duties in Dr. Jarvis' academic lab at the University of Wyoming (http://www.uwyo.edu/molecbio/faculty-and-staff/don-jarvis/). The successful candidate will contribute to our overall effort to create and characterize new baculovirus-insect cell systems designed to produce recombinant glycoproteins with humanized glycosylation profiles. As lab manager, the successful candidate will perform essential support functions, including insect cell culture maintenance, supply procurement, coordinator for equipment maintenance, and will supervise a part time lab aide who will perform other, lower level support functions. As Research Scientist, the successful candidate will directly participate in one or more specific research projects, in most cases, by producing and purifying recombinant protein preparations using our baculovirus-insect cell systems.

Minimal qualifications: M.S. and training in laboratory methods in Molecular Biology, Microbiology, Biochemistry, Virology, Glycobiology, or a related field; strong written and verbal communication skills.
Preferred qualifications: working laboratory experience in methods of molecular biology, virology, and/or glycobiology, recombinant DNA technology, baculovirus-insect cell systems, protein expression and purification, carbohydrate analysis, vaccine development, and/or therapeutic antibody development.

Our research focuses on development and application of glycoengineered baculovirus-insect cell systems for production of vaccines, therapeutic antibodies, and other glycoproteins for direct biomedical applications and/or structural biology. One common theme is an interest in the impact of N-glycan structure on various recombinant glycoprotein functions, including an overall analysis of the clinical efficacy of some products. The working environment and lifestyle in Laramie, WY, a small Rocky Mountain Western college town, are simply outstanding. The salary will be at least $40,000 per year, commensurate with qualifications and experience. For more information or to apply for this position, please send a cover letter describing your scientific background, interests, and qualifications, plus a curriculum vitae to:  dljarvis@uwyo.edu, with a reference to GlycoBac LMRS0615 in the subject line. This position will remain open until a suitable candidate is identified.

GlycoBac, LLC is an Equal Opportunity Employer



Posted March 24, 2015
Research Scientist position in a new biotechnology company, GlycoBac, LLC
Contact:
dljarvis@uwyo.edu

Description:
Dr. Donald Jarvis is seeking a motivated individual to serve as a Research Scientist in a new biotechnology company, GlycoBac, LLC  (http://www.glycobac.com/), which was created to refine and commercialize glycoengineered baculovirus-insect cell platforms developed in his academic lab at the University of Wyoming (http://www.uwyo.edu/molecbio/faculty-and-staff/don-jarvis/). The successful candidate will contribute to an overall team effort to create and characterize new baculovirus-insect cell systems that can be used to produce recombinant glycoproteins with humanized glycosylation profiles, as well as other glycoengineering efforts supported by the NIH SBIR program.

Minimal qualifications: Ph.D. and training in laboratory methods in Molecular Biology, Microbiology, Biochemistry, Virology, Glycobiology, Cell Biology, or a related field; primary publications in refereed English language journals; strong written and verbal communication skills.

Preferred qualifications: working laboratory experience in methods of molecular biology, virology, and/or glycobiology, recombinant DNA technology, baculovirus-insect cell systems, protein expression and purification, carbohydrate analysis, vaccine development, and/or therapeutic antibody development.

The successful candidate will work independently on NIH-funded projects involving development and application of glycoengineered baculovirus-insect cell systems for production of vaccines, therapeutic antibodies, and other glycoproteins for direct biomedical applications and studies on the impact of N-glycan structure in clinical efficacy and structural biology. The working environment and lifestyle in Laramie, WY, a small Rocky Mountain Western college town, are simply outstanding. The salary will be at least $40,000 per year, commensurate with qualifications and experience. For more information or to apply for this position, please send a cover letter describing your scientific background, interests, and qualifications, plus a curriculum vitae to:  dljarvis@uwyo.edu, with a reference to GlycoBac RS0315 in the subject line. This position will remain open until a suitable candidate is identified.

GlycoBac, LLC is an Equal Opportunity Employer


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