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Posted May 9, 2013

Postdoctoral position

Contact: Please send CV, statement of current interests and a list of references to dennis@lunenfeld.ca with "Metabolomics Project" in the subject line.

Description:

The Dennis laboratory at Samuel Lunenfeld Research Institute in Toronto has an opening for a PhD graduate with experience in Mass Spectrometry, and an interest in metabolism, protein glycosylation and regulatory networks. A broad expertise in Mass Spectrometry methods and data analysis is required. We have two LC-MS/MS systems, a new Agilent 6550 Q-TOF and ABI4000 QQQ for targeted analysis. Experience in metabolic flux analysis using isotope-labeling is an asset. We are studying the interaction between metabolism, N-glycosylation of growth factor receptors, nutrient transporters, and signal transduction. The experimental models are genetically modified human and mouse cell lines as well as mutant strains of mice which display adult phenotypes associated with metabolism, cancer and autoimmune disease. We also have C. elegans mutations in the hexosamine and Golgi glycosylation pathways with stress phenotypes related to human neurodegenerative diseases. Through collaborations, we have access to clinical samples from cancer, autoimmune and diabetes patients. The successful candidate will be highly motivated, comfortable with technical challenges and problem solving. He/She will work independently on a project, and with our collaborators and on several projects.

The closing date for applications will be 30th July 2013

Please send CV, statement of current interests and a list of references to dennis@lunenfeld.ca with "Metabolomics Project" in the subject line.

Posted May 3, 2013
Postdoctoral Researcher
Contact: http://jobs.ifr.ac.uk or contact Human Resources, Norwich BioScience Institutes Partnership, Norwich Bioscience Institutes, Norwich, NR4 7UA, UK, 01603 450149 quoting reference 1002435

Description:
Applications are invited for a Postdoctoral Researcher to join a new research group led by Dr Norihito Kawasaki on glycobiology and gut immunity at The Institute of Food Research. The focus of the research group is to elucidate gut immune function by focusing on glycan�protein interactions, which may lead to the development of novel therapeutic interventions. Our primary interest is food-borne polysaccharides which can modulate the gut immune system. The research area is at the interface of immunology and glycobiology, and requires multidisciplinary skills and knowledge.

The appointee will undertake research on the immunological analysis of polysaccharides both in vitro and in vivo, and the biochemical analysis of glycan�protein interactions. This is a key appointment within the new research group, and the appointee will work closely with Dr Kawasaki to develop this new area of research at The Institute of Food Research (IFR). He/she will have laboratory management duties, and will be expected to attend scientific seminars and meetings.
The successful candidate should have a PhD in immunology, molecular biology, biochemistry, or relevant fields, and ideally have practical experience in flow cytometry, confocal microscopy, and basic molecular biology experiments. Familiarity with immunology, especially gut immunology and knowledge of glycobiology, will be desirable.

IFR is the publicly funded research institute that addresses the fundamental science underpinning food and health between primary food production and its consumption. Research at IFR is focused on the physical and chemical nature of food and how it interacts with the body to influence health. The Institute also aims to advance understanding of the fundamental biological processes within the gut, involving the interaction between food, the gut microbiota and the human gut epithelium.

Salary on appointment will be within the range �28,100 to �31,300 per annum depending on qualifications and experience. The post is initially funded for three years.

For further information and details of how to apply, please visit our web site http://jobs.ifr.ac.uk or contact Human Resources, Norwich BioScience Institutes Partnership, Norwich Bioscience Institutes, Norwich, NR4 7UA, UK, 01603 450149 quoting reference 1002435.

The closing date for applications will be 30th May 2013

The Institute of Food Research is a registered charity (No 1058499) and is an Equal Opportunities Employer.

Posted March 19, 2013
Postdoctoral Fellowship at Brigham and Women's Hospital / Harvard Medical School
Contact: Matt Opperman; MOPPERMAN@PARTNERS.ORG

Description:
POSTDOCTORAL FELLOWSHIP
DEPARTMENT OF DERMATOLOGY
BRIGHAM AND WOMEN'S HOSPITAL
HARVARD MEDICAL SCHOOL

The Dimitroff Laboratory (http://dimitrofflab.bwh.harvard.edu/) has an opening for a post-doctoral fellowship position to study how lectin-binding carbohydrates are upregulated on malignant melanoma cells and whether these lectin-binding structures are functionally correlated with malignant behavior. This individual will become part of an enthusiastic team approach to solving glyco-pathobiological problems in cancer development. Candidates with knowledge of glycobiology and galectin biology in the context of tumor metastasis or of inflammation are preferred. A strong background in the performance of flow cytometry, real-time RT-PCR, cell adhesion assays, Western blotting, gene transfection/transduction/silencing technologies is required. Necessary qualifications include an M.D., Ph.D., or M.D./Ph.D. degree and excellent communication/written English skills.

Please send curriculum vitae, a statement of current research interests and a list of references to:

Charles J. Dimitroff, Ph.D.
Assistant Professor of Dermatology
Department of Dermatology
Brigham and Women's Hospital
Harvard Medical School
Harvard Institutes of Medicine, Room 662
77 Avenue Louis Pasteur
Boston, MA 02115
Attn: Matt Opperman; MOPPERMAN@PARTNERS.ORG

An Equal Opportunity / Affirmative Action Employer.