Jobs

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Posted: May 17, 2016
Postdoctoral Position Leukemia Research at Children's Hospital Los Angeles, Los Angeles, CA
Contact: Nora Heisterkamp; jgroffen@chla.usc.edu

Description: 
An NIH-supported postdoctoral position will be available to study the role of the leukemia microenvironment, carbohydrate modifications and carbohydrate binding proteins in leukemia cell survival and the development of drug resistance. We are currently studying how Galectins contribute to the communication between stromal cells, leukemia cells and the role of this in promoting drug resistance -see PMID 25869099 and 23760399. 

We are looking for: Experience working with mice, hematopoietic cell tissue culture, retroviral or lentiviral transduction and FACS are required. Expertise in glycobiology or biochemistry is an advantage. Candidates who are interested in following an academic career path, are self-motivated and enjoy the complexity of biological systems are especially encouraged to apply. 

How to apply: Please include your current CV, a 1-page cover letter describing your current position, your reasons for applying and contact details of three recent referees as a single PDF. 

The lab: Our lab is in the Division of Hematology/Oncology and Bone Marrow Transplant at Children's Hospital Los Angeles (CHLA). CHLA is academically affiliated with the Keck School of Medicine of the University of Southern California and is strongly committed to basic, translational and clinical research. The Children's Center for Cancer and Blood Diseases at CHLA is the largest pediatric hematology-oncology program in the United States. We have ongoing collaborations in the area of glycobiology with scientists at the Institute for Glycomics, Griffith University. 


Posted: April 29, 2016
Postdoctoral Associate position at the Sanford Burnham Prebys Medical Discovery Institute (SBP) (La Jolla, CA)
Contact: Dr. Hudson Freeze; azimmon@sbpdiscovery.org.

Description:
A postdoctoral position is immediately available at the Sanford Burnham Prebys Medical Discovery Institute (SBP) to study NGLY1 mutations that cause a recently discovered human neurological disease of protein N-de-glycosylation. The pathological mechanism is unknown. 
 
Our team combines cell biology, biochemistry, and human genetics in solve Congenital Disorders of Glycosylation (CDG) including NGLY1. Fundamental discoveries are aimed at translational applications that can benefit patients. 
 
The postdoc will drive the project to identify consequences of disrupted N-glycan cleavage from misfolded glycoproteins that are retro-translocated into the cytoplasm. Plans include a search for obligate substrates, alternate cleavage pathways, potential therapeutic molecules, and analysis of patient cells. Techniques include gene manipulation, glycan analysis, fluorescence methods, and proteomic analysis.

Close collaborations with other NGLY1 research laboratories, the NIH, and philanthropic organizations provide unique interactive opportunities for the candidate.
 
If interested in this challenging research opportunity in NGLY1, please read PMID: 24651605, PMID: 25900930, and http://www.newyorker.com/magazine/2014/07/21/one-of-a-kind-2
 
Required Skills:
        Recent PhD or MD/PhD with strong motivation and background in biochemistry, genetics, cellular & molecular biology.
        First-author publications in any 2 of the following: biochemistry, cell biology, glycobiology, gene manipulation, ERAD or cytoplasmic protein degradation.
        Excellent verbal/written communication skills in fluent English.
        Previous experience in a biochemistry, genetics, or cellular/molecular biology lab based in the United States. 
        Independent self-starter who thrives in a highly interactive, collaborative scientific environment.
 
How to Apply:
Send a single PDF document that includes all of the following:
        Your current CV
        1 page letter outlining your background, specific interest in NGLY1, and how you would like to study it.
        3 recent reference contacts for this project.
 
Email the PDF document to Dr. Hudson Freeze at azimmon@sbpdiscovery.org.


Posted: April 27, 2016
NIH-supported postdoctoral position: Regulation of Immunity and Glycosylation In The Endoplasmic Reticulum (Dallas, TX)
Contact: Mark.Lehrman@UTSouthwestern.edu

Description:
An NIH-supported postdoctoral position is available in a collaboration between Dr. Mark Lehrman, Department of Pharmacology, and Dr. Nan Yan, Departments of Immunology and Microbiology, UT Southwestern Medical Center at Dallas.  The collaboration focuses on TREX1/DNaseIII, an endoplasmic reticulum-associated exonuclease that regulates autoimmunity.  TREX1 defects account for several human disorders.  We recently found that TREX1 controls oligosaccharyltransferase function in a disease-specific manner (Hasan et al. (2015) Immunity 43:463-474).  Projects include examination of TREX1-dependent immunogenic free glycans, and proteomic identification of underglycosylated antigenic epitopes exposed by TREX1 dysfunction.  Explorations of other aspects of glycosylation and immunity are also being developed.  The work is driven by availability of rigorous biochemical and genetic glycobiological approaches, patient-derived cells, and mouse models of TREX1 disorders. Please see:


Candidates must hold a Ph.D. or comparable degree, with experience in glycobiology, immunology, microbiology, or biochemistry.  Interested individuals should send a CV, statement of interests, and a list of three references to:

Mark Lehrman, Ph.D.
Professor, Department of Pharmacology
UT Southwestern Medical Center
6001 Forest Park Rd. 
Dallas, TX 75390-9041

UT Southwestern is an Equal Opportunity, Affirmative Action Employer

Posted: February 5, 2016
Postdoc or Research Scientist opening at Van Andel Research Institute (Grand Rapids, MI)

Van Andel Research Institute's Haab Laboratory, led by Brian Haab, Ph.D. is seeking to hire either a Postdoctoral Researcher or a Research Scientist. 

Van Andel Research Institute (VARI), a leading independent biomedical research facility, is dedicated to determining the epigenetic, genetic, molecular and cellular origins of cancer, Parkinson's and other diseases, and translating those findings into effective therapies. The Institute is home to more than 200 scientists and support staff that work in on-site laboratories and in collaborative partnerships that span the globe.

The Haab Laboratory works to enable the more accurate diagnosis and prognosis of pancreatic cancer. The laboratory develops new approaches to the molecular characterization of subtypes of pancreatic cancer and translates the information into clinical tests. Glycobiology is a major focus. The position is available immediately.

Qualifications:
- A Ph.D. (or equivalent degree) with experience and publications in the fields of molecular biology and/or analytical chemistry and/or scientific computing and programming.

Description of a Successful Candidate:
- A dedicated researcher with commitment to the highest scientific and ethical standards
- A creative scientist who can independently advance research
- A team player
- To sum it up: creative, motivated, collaborative, and optimistic, with a desire to impact human health

The Project:
The project involves developing and applying new methods to characterize and measure protein glycoforms in clinical samples; determining relationships between molecular and clinical information; developing and applying in vivo and in vitro assays for functional analysis; and working with many collaborators.

This position is a great opportunity to gain expertise in a cutting-edge, clinically-oriented field, and to contribute to high productivity of top-quality publications.

Learn more and apply to this position by visiting http://bit.ly/Cancer-VARI-Postdoc

About Grand Rapids, MI
Van Andel Research Institute is located in downtown Grand Rapids, MI which is the second largest city in Michigan and the largest city in West Michigan. Grand Rapids offers a remarkable combination of cosmopolitan atmosphere and small town warmth, known for its philanthropic and sustainability-driven community, and is ranked one of "America's Top 100 Places to Live."
Located on the banks of the Grand River, Grand Rapids offers all the big-city excitement you'd expect from a million-resident metropolis, featuring hundreds of restaurants and nightspots, theatres, museums, sports and concerts. The safe and clean downtown is surrounded by an eclectic mix of walk-able neighborhoods.

With a medical and life sciences industry boom, strong entrepreneurial activity, dedication to green building and living, and innovative employers, Grand Rapids' diverse economy continues to grow, offering endless career opportunities.

Van Andel Institute is an EEO and Affirmative Action Employer of Females/Minorities/Veterans/ Individuals with Disabilities. Accordingly, as an Equal Employment Opportunity Employer, Van Andel Institute's employment selection and related decisions are made without regard to sex, race, height, weight, age, disability, religion, national origin, color, marital or veteran status, or any other class protected by federal, state, or local law.



Posted: January 12, 2016
Postdoctoral associate positions at Boston University
Contact: Joseph Zaia - jzaia@bu.edu

Description:
Laboratory of Joseph Zaia
Department of Biochemistry
Center for Biomedical Mass Spectrometry
Boston University

We are recruiting post-doctoral associates to work on NIH supported projects in the Zaia group at Boston University. Our group uses mass spectrometry methods for studying disease processes in tissue using combined proteomics, glycomics and glycoproteomics. We have two openings for postdoctoral scientists:

1. Combined proteomics and glycomics from histological tissue. Aberrant glycosaminoglycan expression is involved in many neurological diseases. The work will involve combined glycomics and proteomics to determine the roles of proteoglycan expression in neurological diseases.
2. Mass spectrometry of glycosaminoglycans. This position involves: 
a. Activated electron dissociation (ExD) methods for sequencing of glycosaminoglycan saccharides. This will involve use of the 12T Bruker Solarix in the laboratory and interaction with bioinformaticists to develop a sequencing platform.
b. Advanced LC-MS methods for intact glycosaminoglycans, including heparins, low molecular weight heparins and chondroitin sulfates.

Competitive salary and benefits are available commensurate with experience. Fluent spoken English, a strong publication track record, and a cooperative attitude are a must for this position. The Zaia group is part of the Center for Biomedical Mass Spectrometry at Boston University. This highly collaborative group provides excellent opportunities for career development of a young Ph.D. scientist.

Candidates should have a recent Ph.D. in analytical chemistry, biochemistry, or a related biomedical field with strong experience with mass spectrometry. Candidates should send curriculum vitae, cover letter, and contact information for three letters of reference to jzaia@bu.edu.

Post-doctoral scientists will be compensated according to the NIH rate: https://grants.nih.gov/grants/guide/notice-files/NOT-OD-15-048.html

Boston University is an Equal Opportunity/Affirmative Action employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability, or protected veteran status.

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