Wednesday, November 9, 2005
7:05 PM
NEW TECHNOLOGIES FOR GLYCOBIOLOGY
Chair: Anne Dell, Imperial College, London, United Kingdom
7:05 PM New technologies to simplify glycomics; Anders Lohse, Rita Martins, Malene R Jorgensen, Mads D Sorensen and Ole Hindsgaul; Carlsberg Laboratory, Gamle Carlsberg Vej 10, DK-2500 Valby-Copenhagen, Denmark 1
7:30 PM New strategies for glycan modification and derivatization and enhancement of glycan arrays; Baoyun Xia1, Ziad S. Kawar1, Tongzhong Ju1, Richard A. Alvarez1, Goverdhan P. Sachdev2 and Richard D. Cummings1; [1] Dept. Biochem. & Mol. Biol., and the Oklahoma Center for Medical Glycobiology, Univ. of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, [2] College of Pharmacy, and the Oklahoma Center for Medical Glycobiology, Univ. of Oklahoma Health Sciences Center, Oklahoma City, OK 73104 2
7:55 PM Understanding carbohydrate antigenicity: Streptococcus agalactiae (Type III) versus Streptococcus pneumoniae (Type 14); Renuka Kadirvelraj1, Jorge Gonzalez-Outeiriño1, Harold J. Jennings2, Simon Foote2 and Robert J. Woods1; [1] Complex Carbohydrate Research Center, University of Georgia, 315 Riverbend Road, Athens, Georgia 30602, USA., [2] Institute for Biological Sciences, National Research Council of Canada, 100 Sussex Drive, Ottawa, Ontario, Canada K1A 0R6 3
8:20 PM Noninvasive imaging of glycosylation in vivo; Jennifer A. Prescher1, Danielle H. Dube1, Anderson Lo1 and Carolyn R. Bertozzi1,2,3; [1] Departments of Chemistry, [2] Molecular and Cell Biology, [3] and Howard Hughes Medical Institute, University of California, Berkeley 4
8:25 PM A profile HMM for tree structures to locate glycan structure profiles; Kiyoko F. Aoki-Kinoshita, Nobuhisa Ueda, Hiroshi Mamitsuka, Susumu Goto and Minoru Kanehisa; Bioinformatics Center, Institute for Chemical Research, Kyoto University, Gokasho, Uji, Kyoto, Japan 611-0011 5
8:30 PM Analyses of carbohydrate recognition by mammalian sialic acid binding proteins of the immune system, Siglecs, using microarrays of lipid-linked oligosaccharide probes.; Maria-Asuncion Campanero-Rhodes1, Paul Crocker2, Robert A Childs1, Wengang Chai1 and Ten Feizi1; [1] The Glycosciences Laboratory, Imperial College, Northwick Park and St Mark’s Campus, Harrow, HA1 3UJ, UK, [2] Wellcome Trust Biocentre, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK 6
Thursday, November 10, 2005
8:30 AM
PROTEOGLYCAN FUNCTIONS
Chair: Jeffrey D. Esko, UCSD, La Jolla, CA
8:30 AM Sulfotransferases: Tuning heparan sulfate functions in neural cell migration and development; Jeremy Turnbull, Scott Guimond and Tarja Kinnunen; School of Biological Sciences, University of Liverpool, Crown Street, Liverpool, L69 7ZB, England, UK 7
8:55 AM HSPGs and sorting of retinal axons in the zebrafish optic tract; Chi-Bin Chien; Dept. Neurobiology & Anatomy, 401 MREB, University of Utah, 20 North 1900 East, Salt Lake City, UT 84132 8
9:20 AM Proteoglycans in axon regeneration and plasticity in the adult CNS; James W Fawcett; Cambridge University Centre for Brain Repair, Robinson Way, Cambridge CB2 2PY, UK 9
9:45 AM A large panel of phage display-derived human antibodies against specific glycosaminoglycan epitopes: versatile tools for the glycobiologist; Guido J. Jenniskens and Toin H. van Kuppevelt; Dept. of Matrix Biochemistry, University Medical Center Nijmegen, Nijmegen Center for Molecular Life Sciences, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands 10
9:50 AM Msulf1 and Msulf2 differentially modify heparan sulphate 6-O sulphation patterning; William Christopher Lamanna1, Rebecca Baldwin2, Cathy Merry2 and Thomas Dierks1; [1] Department of Biochemistry, University of Bielefeld, 33615, Bielefeld, Germany, [2] Department of Medical Oncology, University of Manchester, Christie Hospital NHS Trus, Wilmslow Road, Manchester 20 4BX 11
9:55 AM Functions of heparan sulfate proteoglycans and the Kallman syndrome protein KAL-1 in C. elegans embryogenesis; Martin L. Hudson1, Tarja Kinnunen2, Jeremy E. Turnbull2 and Andrew D. Chisholm1; [1] Department of Molecular, Cellular and Developmental Biology, University of California, Santa Cruz, CA, 95064, USA, [2] School of Biological Sciences, University of Liverpool, Crown St, Liverpool, L69 7ZB, UK 12
10:30 AM
EVOLUTION OF GLYCANS AND GLYCAN FUNCTION
Chair: Christopher West, University of Oklahoma HSC, Oklahoma City, OK
10:30 AM The basic principles of N-linked protein glycosylation; Markus Aebi.; Institute of Micorbiology, Department of Biology, Swiss Federal Institute of Technology (ETH), CH-8093 Zürich, Switzerland 13
10:55 AM Egghead and Brainiac are essential for glycosphingolipid biosynthesis in vivo; Hans H Wandall1, Sandrine Pizette2, Johannes W Pedersen1, Heather Eichert3, Steven B Levery3, Ulla Mandel1, Stephen M Cohen2 and Henrik Clausen1; [1] Faculty of Health Sciences, University of Copenhagen, Nørre Allé 20, 2200 Copenhagen N, Denmark, [2] European Molecular Biology Laboratory, Meyerhofstr 1, 69117 Heidelberg, Germany, [3] Department of Chemistry, University of New Hampshire, Durham, NH 03824 14
11:20 AM Structural and evolutionary aspects of animal lectins: Diversity in glycan recognition; Gerardo R. Vasta.; Center of Marine Biotechnology, University of Maryland Biotechnology Institute, Columbus Center Suite 236, 701 E Pratt Street, Baltimore, MD 21202 15
11:45 AM Regulation of Notch signaling by glycosylation; Kenneth D Irvine, Nicola Haines, Liang Lei, Tetsuya Okajima and Aiguo Xu; Waksman Institute, 190 Frelinghuysen Rd, Rutgers University, Piscataway NJ 08904 USU 16
12:10 PM N-Acetylglucosaminyltransferase I-dependent N-glycans are involved in the response of Caenorhabditis elegans to bacterial pathogens; Harry Schachter1,2, Hui Shi1 and Andrew M. Spence3; [1] Program in Structural Biology and Biochemistry, The Hospital for Sick Children, 555 University Avenue, Toronto, Ont., Canada M5G 1X8 , [2] Department of Biochemistry, University of Toronto, 1 King’s College Circle, Toronto, Ont., Canada M5S 1A8 , [3] Department of Molecular and Medical Genetics, University of Toronto, 1 King’s College Circle, Toronto, Ont., Canada M5S 1A8 17
12:15 PM O-GlcNAc cycling enzymes modulate life span in C. elegans; Olga Stuchlik1, Mohammad M. Rahman2, Edward T. Kipreos2 and Lance Wells1; [1] Complex Carbohydrate Research Center, [2] Department of Cellular Biology, University of Georgia 18
12:20 PM O-Glucosylation of Notch1 and its significance in Notch signaling.; Aleksandra Nita-Lazar, Rosemary Orhue and Robert S. Haltiwanger; Department of Biochemistry and Cell Biology, Institute for Cell and Developmental Biology, Stony Brook University, Stony Brook, NY 11794-5215 19
4:00 PM
NEUROGLYCOBIOLOGY
Chair: Karen Colley, University of Illinois at Chicago, Chicago, IL
4:00 PM Polysialic acid-dependent cell migration is essential for mammalian brain development; Minoru Fukuda.; The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037 20
4:25 PM Polysialic acid is essential to control NCAM functions during mouse development; Birgit Weinhold1, Iris Röckle2, Martina Mühlenhoff1, Ralph Seidenfaden3, Herbert Hildebrandt2 and Rita Gerardy-Schahn1; [1] 1Zelluläre Chemie, Zentrum Biochemie, Medizinische Hochschule Hannover, Carl-Neuberg-Straße 1, 30625 Hannover, Germany, [2] Institut für Zoologie, Universität Hohenheim, Garbenstr. 30, 70593 Stuttgart, Germany, [3] Institut de Biologie du Développement de Marseille, Campus de Luminy, 13288 Marseille 9, France 21
4:50 PM Glycosphingolipids in nervous system development, stability and disease; Richard L. Proia.; NIDDK, NIH, Bethesda, MD 22
5:15 PM Human GM3 synthase deficiency: a novel form of hereditary childhood epilepsy; David A Priestman1, David C A Neville1, Gabriele Reinkensmeier1, Michael A Simpson2, Christos Proukakis2, Michael Patten2, Raymond A Dwek1, Terry D Butters1, Frances M Platt1 and Andrew H Crosby2; [1] Glycobiology Institute, Department of Biochemistry, South Parks Road, University of Oxford, Oxford, OX1 3QU, UK, [2] Department of Medical Genetics, St. George’s Hospital Medical School, University of London, Cranmer Terrace, London SW17 0RE, UK 23
5:40 PM Substrate reduction therapy reduces brain ganglioside GM2 in neonatal Sandhoff disease mice; Rena C. Baek1, Julie L. Kasperzyk1, Frances M. Platt2 and Thomas N. Seyfried1; [1] Department of Biology, Boston College, Chestnut Hill, MA, USA, [2] Glycobiology Institute, Department of Biochemistry, University of Oxford, Oxford, UK 24
5:45 PM Protein specific polysialylation of NCAM by polysialyltransferases; Shalu Shiv Mendiratta, Nikolina Sekulic, Arnon Lavie and Karen J. Colley; Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, College of Medicine, Chicago, Illinois 60607 25
5:50 PM Role of sialyltransferase in the nervous system development of Drosophila; Elena A. Repnikova1, Kate Koles1, Jarred Pitts1, Christina Ramos1, Eduardo J. Garza1, Stylianos Kosmidis2, Efthimios M.C. Skoulakis2 and Vlad M. Panin1; [1] Department of Biochemistry/Biophysics, Texas A&M University, College Station, 77843-2128, Texas, USA, [2] Alexander Fleming Biomedical Research Center, Vari, Greece, 16602 26
Friday, November 11, 2005
8:15 AM
GLYCANS AND LECTINS IN PATHOGEN RECOGNITION
Chair: Tamara L. Doering, Washington University School of Medicine, St. Louis, MO
8:15 AM Genetic analysis of pathways required for the assembly of the surface glycocalyx coat of the protozoan parasite Leishmania and their roles in the infectious cycle; Stephen M. Beverley1, Althea Capul1, Kai Zhang1 and Salvatore J. Turco2; [1] Dept. of Molecular Microbiology, Washington University School of Medicine, 660 S. Euclid Ave., St. Louis MO 63105 USA, [2] Dept. of Biochemistry, University of Kentucky Medical School, Lexington KY 40536 USA. 27
8:40 AM Lipophosphoglycan-galectin interactions controlling sand fly vector competence for Leishmania major; David Sacks1, Shaden Kamhawi1, Marcelo Ramalho-Ortigao1, Phillip Lawyer1 and Jesus Valenzuela2; [1] Laboratory of Parasitic Diseases, NIAID, NIH, Bethesda MD, 20892, [2] Laboratory of Malaria and Vector Research, NIAID, NIH, Bethesda MD, 20892 28
9:05 AM Mannnose 6-phosphate receptors and the pathogenesis of infections due to varicella zoster virus; Michael D. Gershon.; Department of Anatomy & Cell Biology 29
9:30 AM Identification and functional characterisation of a UDP-glucose pyrophosphorylase from Leishmania major; Anne-Christin Lamerz1, Barbara Kleczka1, Martin Wiese2, Francoise Routier1, Ger van Zandbergen3, Tamas Laskay3, Werner Solbach3 and Rita Gerardy-Schahn1; [1] Department of Cellular Chemistry, Medizinische Hochschule Hannover, Hannover, Germany , [2] Bernhard-Nocht-Institute for Tropical Medicine, Hamburg, Germany, [3] Institute for Medical Microbiology and Hygiene, Innovations Campus Lübeck, Lübeck, Germany 30
9:35 AM Origin of the galacturonic acid modifications to the inner core of Rhizobium leguminosarum lipopolysaccharides; Suparna Kanjilal, Shib. S. Basu, Margaret. I. Kanipes and C. R. H. Raetz; Department of Biochemistry, Duke University Medical Center, Durham, NC 27710 31
9:40 AM Pathogen capture in water using glycoprotein micelles; Elaine H. Mullen1, Baddr A. Shakhsheer1, Jason J. Quizon2, James C. Crookston2, Miquel D. Antoine2 and Juan Arroyo1; [1] The MITRE Corporation, 7515 Colshire Drive, McLean, VA 22102, [2] Johns Hopkins University Applied Physics Lab, 11000 Johns Hopkins Road, Laurel, MD, 20723 32
10:15 AM
GLYCAN IMMUNOLOGY
Chair: Richard D. Cummings, University of Oklahoma HSC, Oklahoma City, OK
10:15 AM Development of a conjugate vaccine against Haemophilus influenzae type b based on synthetic antigens; Vicente Verez-Bencomo1, Violeta Fernandez-Santana1, Eugenio Hardy2, Maria Eugenia Toledo3, Rene Roy4, Maria C Rodriguez1, Arlene Rodriguez2, Lazaro Heynngnezz2, Alberto Baly3, Mabel Izquierdo2, Annette Villar1, Yury Valdes1, Karelia Kosme2, Mercedes Deler1, Manuel Montane2, Ernesto Garcia1, Alexis Ramos1, Aristides Aguilar2, Ernesto Medina2, Gilda Toraño3, Ivan Sosa2, Ibis Hernandez3, Raydel Martinez3, Alexis Mussachio2, Ania Carmenate5, Lourdes Costa2, Olga L Garcia2 and Luis Herrera2; [1] (1) Center for the Study of Synthetic Antigens, Faculty of Chemistry, University of Havana, [2] Center for Genetic Engineering and Biotechnology, Havana, Cuba, [3] Institute of Tropical Medicine Pedro Kouri, Havana, Cuba, [4] Department of Chemistry, Université du Québec à Montréal, [5] Camaguey Public Health Center 33
10:40 AM C-type lectins on dendritic cells: antigen receptors and modulators of immune responses; Y. van Kooyk, S. van Vliet, I. van Die and T.B.H. Geijtenbeek; Department of Molecular Cell Biology and Immunology VU University Medical Center Amsterdam, v.d. Boechorststraat 7, 1081 BT Amsterdam, the Netherlands 34
11:05 AM Structural basis of DC-SIGN ligand specificity; Hadar Feinberg1, Yuan Guo2, Edward Conroy2, Daniel Mitchell2, Richard Alvarez3, Ola Blixt4, Maureen Taylor2, Kurt Drickamer2 and William Weis1; [1] Depts. of Structural Biology and Molecular & Cellular Physiology, Stanford University School of Medicine, 299 Campus Drive West, Stanford, CA 94305 USA, [2] Glycobiology Institute, Dept. of Biochemistry, University of Oxford, Oxford OX1 3QU, UK, [3] Dept. of Biochemistry & Molecular Biology, University of Oklahoma Health Science Center, Oklahoma City, OK 73104 USA, [4] Dept. of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Rd., La Jolla, CA 92037 USA 35
11:30 AM Glycan processing and presentation: The new MHC Class II pathway; Brian A. Cobb.; 10900 Euclid Avenue, Cleveland, OH 44106-7288 36
11:55 AM Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections; Albert Bendelac.; 5841 South Maryland Ave, MC 1089, Chicago, IL 60637 37
12:30 PM
SPECIAL LUNCHTIME DISCUSSION
12:30-2:00 PM Assignment and review of glycobiology-related grant applications by the National Institutes of Health; Donald Schneider; Division of Molecular and Cellular Mechanisms, Center for Scientific Review, NIH, Rockville, MD
4:00 PM
SOCIETY FOR GLYCOBIOLOGY BUSINESS MEETING
4:30 PM
KARL MEYER AWARD LECTURE
Saturday, November 12, 2005
8:30 AM
N-LINKED GLYCAN FUNCTIONS
Chair: Michael Pierce, University of Georgia, Athens, GA
8:30 AM Gains of glycosylation comprise an unexpectedly large group of pathogenic mutations; Jean-Laurent Casanova.; INSERM U550 Faculté de Médecine Necker 156 rue de Vaugirard 75015 Paris France 38
8:55 AM Hexosamine, N-glycans and cytokine signaling - A regulatory network; Ken Lau1, Emily A Partridge1, Pam Cheung1, Rick Mendelsohn1, Cristina I Silvescu2, Vern N Reinhold2 and James W Dennis1; [1] Samuel Lunenfeld Research Institute, Mount Sinai Hospital, and University of Toronto, 600 University Ave, Toronto, ON, Canada, [2] Chemistry, University of New Hampshire, Durham, NH 39
9:20 AM Dietary and genetic control of pancreatic beta cell glucose transporter-2 glycosylation promotes insulin secretion in suppressing the pathogenesis of Type 2 diabetes; Kazuaki Ohtsubo1, Shinji Takamatsu2,3, Mari T. Minowa2, Aruto Yoshida2, Makoto Takeuchi2 and Jamey D. Marth1; [1] Howard Hughes Medical Institute and Department of Cellular and Molecular Medicine, 9500 Gilman Drive, University of California San Diego, La Jolla, California, 92093, [2] Central Laboratories for Key Technology, Kirin Brewery Co. Ltd. 1-13-5, Fuku-ura, Kanazawa-ku, Yokohama, Kanagawa 236-0004, Japan, [3] Biomedical Imaging Research Center, University of Fukui, 23-3 Shimoaizuki, Matsuoka, Yoshida, Fukui, 910-1193 Japan 40
9:45 AM N-glycosylation-dependent apical trafficking of the sialomucin endolyn in polarized epithelial cells; Beth A. Potter1, Kelly M. Weixel1, Jennifer R. Bruns1, Gudrun Ihrke2 and Ora A. Weisz1; [1] Renal-Electrolyte Division, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, [2] Clinical Biochemistry, Cambridge Institute for Medical Research, University of Cambridge, United Kingdom 41
9:50 AM HIV envelope glycoproteins: modification of glycans and glycan dependent folding pathways provide new targets for vaccine design and anti-viral therapies; Pauline M Rudd, Christopher S Scanlan, Stephanie Pollock and Raymond A Dwek; Glycobiology Institute, University of Oxford, South Parks Road, Oxford, OX1 3QU 42
9:55 AM Characterization of a human core-specific lysosomal a1-6 mannosidase involved in N-glycan catabolism; Kelley W. Moremen1,2, Chaeho Park1,2, Lu Meng2, Leslie Stanton1, Robert E. Collins1, Steven Mast1,2, Yaiobing Yi2 and Heather Strachan1,2; [1] Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602, [2] Complex Carbohydrate Research Center, University of Georgia, Athens, GA 30602 43
Saturday, November 12, 2005
10:30 AM
GLYCANS IN IMMUNE SYSTEM REGULATION
Chair: Jamey D. Marth, University of California, San Diego, San Diego, CA
10:30 AM CD22: a multi-functional lectin that regulates B lymphocyte survival and signal transduction; Thomas F Tedder, Jonathan C Poe and Karen M Haas; Dept of Immunology, Box 3010, Durham, NC 27710 44
10:55 AM CD22-Ligand interactions in BCR-signaling; Brian E. Collins1, Shoufa Han1, Brian A. Smith2, Per Bengtson1, Hiroaki Tateno1, Nicolai Bovin3, Ola Blixt1 and James C. Paulson1; [1] Department of Molecular Biology, The Scripps Research Institute, La Jolla CA 92037, [2] The Sidney Kimmel Cancer Center, La Jolla, CA 92037, [3] Shemyakin & Ovchinnikov Institute of Bioorganic Chemistry 45
11:20 AM Siglec-8: an inhibitory receptor on eosinophils and mast cells; Bruce Bochner1, Hidenori Yokoi1, Esra Nutku1, Paul Crocker2, Nicholai V. Bovin3, Ronald L. Schnaar4 and Nives Zimmermann5; [1] Department of Medicine, Division of Allergy and Clinical Immunology, Johns Hopkins University School of Medicine, Baltimore, MD, [2] Division of Cell Biology and Immunology, The Wellcome Trust Biocentre, University of Dundee, Dundee, UK, [3] Shemyakin & Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia, [4] Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, [5] Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 46
11:45 AM Probing the functions of Siglecs expressed on myeloid cells; Paul R Crocker, Cornelia Oetke and Tony Avril; Division of Cell Biology and Immunology, The Wellcome Trust Biocentre, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK. 47
12:10 AM Regulation of intracellular immune signal transduction by protein glycosylation: Setting thresholds for B lymphocyte activation and immunoglobulin homeostasis; Pam Grewal, Mark Boton, Kevin Ramirez, Akira Saito, Ryan Green, Kazuaki Ohtsubo, Daniel Chui and Jamey Marth; Howard Hughes Medical Institute and the Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, California, 92093 48
12:15 AM P-selectin expression in the thymus is required for importation of T cell progenitors and is modulated by thymic T cell production; Klaus Gossens, Stephane Y. Corbel, Fabio M. Rossi and Hermann J. Ziltener; The Biomedical Research, Centre University of British Columbia, 2222 Health Sciences Mall, Vancouver BC. V6T 1Z3 Canada 49
12:20 AM Lymphocyte trafficking in mice deficient in MECA-79 antigen: analysis of core 1 extension enzyme (b1,3-N-acetylglucosaminyltransferase-3) knockout mice; Junya Mitoma1, Jean-Marc Gauguet2, Bronislawa Petryniak3, Hiroto Kawashima1, Patrick Schaerli2, John B. Lowe3, Ulrich H. von Andrian2 and Minoru Fukuda1; [1] Glycobiology Program, Cancer Research Center, The Burnham Institute, 10901 N. Torrey Pines Road, La Jolla, CA 92037, [2] Howard Hughes Medical Institute, Department of Pathology, The University of Michigan Medical School, Ann Arbor, Michigan 48109, [3] CBR Institute for Biomedical Research, Harvard Medical School, Boston, MA 02115 50
Saturday, November 12, 2005
4:00 PM
GLYCANS IN DISEASE
Chair: Linda G. Baum, UCLA School of Medicine, Los Angeles, CA
4:00 PM Inactivation of the golgi CMP-sialic acid transporter gene reveals a new human Type II congenital disorder of glycosylation (CDGIIf).; Rosella Mollicone1, Thierry Dupre 2, Jean-Jacques Candelier 1, Ivan Martinez-Duncker 1, Gil Tchernia3 and Rafael Oriol1; [1] Inserm U504, Hopital Paul Brousse, University of Paris-Sud XI, Villejuif Cedex 94807, France, [2] Laboratoire Biochimie A, CHU Xavier Bichat, Paris Cedex 75877, France, [3] Laboratoire d'hematologie et Immunologie, CHU Kremlin-Bicetre, 94275 Cedex, France 51
4:25 PM Functional domains in dystroglycan processing and laminin binding; Kevin P Campbell.; HHMI, Dept Physiology and Biophysics, University of Iowa, Iowa City, Iowa 52242. 52
4:50 PM Galectins and the inflammatory response; Fu-Tong Liu.; Department of Dermatology, University of California Davis, 4860 Y Street, Sacramento, CA 95817 53
PRESIDENT'S LECTURE
Chair: Ronald L. Schnaar, Johns Hopkins School of Medicine, Baltimore, MD
5:15 PM Hepatic clearance of triglyceride-rich lipoproteins depends on heparan sulfate; Jennifer M. MacArthur1, Lianchun Wang1, Joseph R. Bishop1, Andre Bensadoun2, Joseph L. Witzum3 and Jeffrey D. Esko1; [1] Department of Cellular and Molecular Medicine, Glycobiology Research and Training Center, University of California, San Diego, La Jolla, CA, 92093, [2] Division of Nutritional Sciences, Cornell University, Ithaca, New York 14853, [3] Department of Medicine, University of California, San Diego, La Jolla, California 92093 54