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Important Dates
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| Deadline |
Item |
| Friday, July 19, 2002 |
Submission of Abstracts |
| Thursday, August 01, 2002 |
Karl Meyer Award Nominations |
| Thursday, August 01, 2002 |
Travel Stipend Applications |
| Wednesday, October 09, 2002 |
Advance Rate Conference Registration |
| Wednesday, October 09, 2002 |
Advance Rate Hotel Reservations |
| Thursday, October 10, 2002 |
Web Publication of Abstracts |
| Saturday, November 09, 2002 |
Satellite Meetings |
| Saturday, November 09, 2002 |
Meeting Starts |
| Tuesday, November 12, 2002 |
Meeting Ends |
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Program
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| Saturday, November 9 |
| 7:00 - 8:30 pm |
CONFERENCE OPENING
- Welcome: James Paulson, The Scripps Research Institute
- Keynote Address: Kurt Drickamer, University of Oxford. A Genomic View of Carbohydrate-Recognition Proteins
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| 8:30 - 10:00 pm |
WELCOME RECEPTION |
| Sunday, November 10 |
| 8:30 - 10:10 am |
CRP-1: C-TYPE LECTINS Chair: Richard D. Cummings, University of Oklahoma
Invited Speakers
- Yvette van Kooyk, VU Medical Center. Immune Function of C-Type Lectins on Dendritic Cells.
- Sem Saeland, Schering-Plough Research. Langerin, a C-Type Lectin of Langerhans-Type Dendritic Cells: A Pathway for Processing or Retention of Glycosylated Antigens?
- Nobutaka Wakamiya, Asahikawa Medical College. Roles of the Membrane Type Collectin CL-P1 in Vascular Endothelial Cells.
Short Talks
- Irma Van Die, VU Medical Center. The dendritic cell specific C-type lectin DC-SIGN recognizes Lewis x, a major glycan epitope of Schistosoma mansoni egg antigen
- Anne Leppanen, University of Oklahoma. Binding of L-selectin to a glycosulfopeptide requires tyrosine sulfation.
- Noorjahan Panjwani, Tufts University School of Medicine. Galectin-3 and -7, but not galectin-1, play a role in re-epithelialization of wounds
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| 10:10 - 10:40 am |
BREAK |
| 10:40 - 12:20 pm |
MEDICAL GLYCOBIOLOGY Chair: Hudson Freeze, The Burnham Institute
Invited Speakers
- Ram Sasisekharan, Massachusetts Institute of Technology. Dynamic Regulationof Tumor Growth and Metastasis by Heparan Sulfate Glycosaminoglycans.
- Jeff Esko, University of California, San Diego. A Murine Model for Hereditary Multiple Exostosis (HME).
- John S. Logan, VP Research, DNX Corp. Overcoming Glycosylation Dependent Acute Rejection in Xenotransplantation.
Short Talks
- Stephan Hinderlich, Institut für Molekularbiologie und Biochemie. Is hereditary inclusion body myopathy a glycosylation disease?
- Roy Jefferis, University of Birmingham. Glycosylation of therapeutic monoclonal antibodies: structural features and biological consequences.
- Tomio Yabe, Tokyo Metropolitan Institute for Neuroscience. Brain specific 3OST isoforms facilitate cellular entry of Herpes virus I.
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| 12:20 - 2:00 pm |
LUNCH BREAK |
| 2:00 - 4:00 pm |
POSTER SESSION AND EXHIBITS |
| 4:00 - 4:30 pm |
Karl Meyer Award Lecture |
| 4:30 - 6:10 pm |
CRP-2:SELECTINS Chair: Kurt Drickamer, University of Oxford.
Invited Speakers
- John Lowe, University of Michigan Medical Center. Selectin ligands and leukocyte biology.
- Geoffrey Kansas, Northwestern University Medical School. Control of Selectin Ligand Biosynthesis in Activated T Cells.
- Uli von Andrian, Harvard Medical School. In Vivo Analysis of Endothelial Selectin Ligands.
Short Talks
- Hiroto Kawashima, The Burnham Institute. High Endothelial Venule-Restricted Sulfotransferase and Core 2 Branching b1,6-N-acetylglucosaminyltransferase Exert Collaborative, Dominant Control Over Lymphocyte Homing.
- Junya Mitoma, The Burnham Institute. Sialyl Lewis x in extended core1 mucin-type O-glycans: Novel L-selectin ligand in neutrophil-neutrophil interaction.
- Karen R. Snapp, Northwestern Medical School. Structural modifications of PSGL-1 required for adhesion and entry of the causative agent of Human Granulocytic Ehrlichiosis (HGE).
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| Monday, November 11 |
| 8:30 - 10:10 am |
GLYCOIMMUNOLOGY: NEW DIRECTIONS Chair: Linda Baum, University of California, Los Angeles.
Invited Speakers
- Ellis Reinherz, Harvard Medical School and Dana Farber Cancer Institute. Glycobiology and Immune Recognition by T Lymphocytes.
- Santos Mañes, Universidad Autonoma de Madrid. Role of Glycosphingolipid-Enriched Membrane Raft Domains in the Polarization of Migrating Cells.
- Ian Wilson, The Scripps Research Institute. Carbohydrate Recognition in the Immune System.
Short Talks
- Shihao Chen, The Burnham Institute. Natural Killer Cells Attack Tumor Cells Expressing High Levels of Sialyl Lewis x Oligosaccharides.
- Ardythe L. Morrow, Cincinnati Children's Hospital Medical Center. Human Milk Oligosaccharide Homologs of Lewis Blood Group Epitopes and Protection against Diarrhea in Breastfed Infants.
- Pauline M. Rudd, University of Oxford. A novel form of carbohydrate recognition. The broadly neutralizing Anti-HIV-1 antibody 2G12 recognizes a cluster of a1-2 mannose residues on the outer face of GP120.
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| 10:10 - 10:40 am |
BREAK |
| 10:40 - 12:20 pm |
GLYCOMICS Chair: Vernon Reinhold, University of New Hampshire.
Invited Speakers
- Anne Dell, Imperial College of Science, Technology & Medicine. Ultra-High Sensitivity Screening of the Glycomes of Mammals and Model Organisms.
- Nicolle Packer, Proteome Systems Ltd. Glycoproteomics: Realistic Expectations.
- Willi von der Lieth, Deutsches Krebsforschungszentrum. Developing Bioinformatics Tools for Glycomics.
Short Talks
- John F. Cipollo, Boston University, Goldman School of Dental Medicine. The Fine Structure of Caenorhabditis elegans N-glycans.
- Heidi A. Geiser, University of New Hampshire.HTP Proteome-Glycome Analysis in Caenorhabditis elegans.
- Elena M. Comelli,The Scripps Research Institute. A comprehensive study of glycosyltransferase gene expression at different stages of lymphocyte activation.
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| 12:20 - 2:00 pm |
LUNCH BREAK |
| 12:30 - 2:00 pm |
Board of Directors Meeting |
| 2:00 - 4:00 pm |
POSTER SESSION AND EXHIBITS |
| 4:00 - 5:40 pm |
DEVELOPMENTAL GLYCOBIOLOGY Chair: Jeff Esko, University of California School of Medicine, San Diego.
Invited Speakers
- Minoru Fukuda, The Burnham Institute. Roles of Polysialic Acid in Neural Development and Cancer.
- Paul Martin, University of California School of Medicine, San Diego. Role of Dystroglycan Glycosylation in Neuromuscular Development and Muscular Dystrophy.
- Robert S. Haltiwanger, State University of New York at Stony Brook. O-Linked Glycosylation of EGF Repeats in Development: Effects of O-Fucose on Notch and Nodal Signaling.
Short Talks
- Kenneth Irvine, Howard Hughes Medical Institute. Regulation of Notch signaling by O-fucose glycans.
- Firoze B. Jungalwala, E. K. Shriver Center at University of Massachusetts Medical School. Glucuronyl glycoconjugates replace the functions of sulfoglucuronyl glycoconjugates in the HNK-1 sulfotransferase null mutant mice.
- Wei-hsuan Yu, Harvard Medical School. A lesson From CD44HSPG Null Mice: Heparan sulfate mediate CD44HSPG transactivating erbB4 pathway implicating the survival mechanism for epithelial/smooth muscle cells during the postpartum reproductive organism extra cellular matrix remodeling.
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| 5:40 - 6:10 pm |
Society Business Meeting |
| 7:00 - 9:00 pm |
CONFERENCE BANQUET |
| Tuesday, November 12 |
| 8:30 - 10:10 am |
CRP-3: SIGLECS Chair: Paul Crocker, Wellcome Trust Biocentre School of Life Sciences, Dundee University.
Invited Speakers
- Paul Crocker, Wellcome Trust Biocentre School of Life Sciences, Dundee University. Probing the Signaling Properties of CD33-Related Siglecs Expressed on Myeloid Cells
- Takashi Angata, University of California School of Medicine, San Diego. Evolutionary Considerations in Understanding Siglec Biology.
- Ronald Schnaar, The Johns Hopkins School of Medicine. Nerve Cell Signaling Induced by MAG/Siglec-4 Binding to Gangliosides.
Short Talks
- Lars Nitschke, Institute of Virology and Immunobioloy, University of Wuerzburg. Sialic-acid binding of CD22 is required for inhibition of the BCR signal.
- Yuzuru Ikehara, The Scripps Research Institute. Analysis of Siglec 7 and 9 subcellular localization following TCR stimulation.
- Brian E. Collins, The Scripps Research Institute. Sialoside Modulation of CD22 Function.
- Soerge Kelm, University Bremen. Sialic acid derivatives as probes for biological functions of Siglecs.
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| 10:10 - 10:40 am |
BREAK |
| 10:40 - 12:20 pm |
FRONTIER TOPICS Chair: Pamela Stanley, Albert Einstein College Medicine.
Invited Speakers
- Gerald Hart, Johns Hopkins University School of Medicine. Dynamic Interplay Between O-GlcNAc and phosphorylation: Roles in Signaling, Stress Responses, and Transcription.
- Marilynn Etzler, University of California Davis. Perception of the Oligosaccharide Signal that Initiates the Rhizobium-Legume Symbiosis.
- Hudson Freeze, The Burnham Institute. Anti-carboxylate antibody mAbGB3.1 blocks onset of Th-1 mediated murine colitis.
Short Talks
- Mark A. Lehrman, UT-Southwestern. Glycogen Phosphorylase, A Candidate Mediator Of Enhancement Of Lipid-linked Oligosaccharide Extension By The Endoplasmic Reticulum Unfolded Protein Response.
- Aleksandra Furmanek, Friedrich Miescher Institute. C-mannosylation of the erythropoietin receptor.
- Toshisuke Kawasaki, Graduate School of Pharmaceutical Sciences, Kyoto University. Requirement of the HNK-1 Carbohydrate for Synaptic Plasticity and Spatial Learning.
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| 12:20 - 2:00 pm |
LUNCH BREAK |
| 2:00 - 4:00 pm |
POSTER SESSION AND EXHIBITS |
| 4:00 - 6:00 pm |
REGULATION OF GLYCOSYLATION Chair: James Paulson, The Scripps Research Institute.
Invited Speakers
- Richard Cummings, University of Oklahoma Health Science Center. Chaperone Function in Regulating O-Glycan Biosynthesis.
- Henrik Clausen, Faculty of Health Sciences, University of Copenhagen. More Functions to the Polypeptide GalNAc-Transferases than Meets the Eye.
- Barbara Imperiali, Massachusetts Institute of Technology. Asparagine-Linked Glycosylation: Causes and Consequences.
- Armando Parodi, Institute for Biotechnological Research University of San Martin. Protein-Protein and Protein-Glycan Interactions in the Recognition of Glycoprotein Conformers.
Short Talks
- Michiko N. Fukuda, The Burnham Institute. Importance of complex type N-glycans in spermatogenesis and neonatal survival: studies of a-mannosidase IIx (MX)-knock out and a-mannosidase II (MII)/MX double knock out mice.
- Emily A. Partridge, Samuel Lunenfeld Research Institute, Mount Sinai Hospital. Regulation of cytokine receptor endocytosis and signal transduction by N-acetylglucosaminyltransferase V (Mgat5).
- Qi Yan, SUNY at Stony Brook. Studies on the Function of Stt3p, an Essential Subunit of Oligosaccharyl Transferase.
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| 6:00 pm |
FAREWELL TOAST |
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