Wednesday, November 11, 1998
|
| 3:00 pm - 10:00 pm |
Registration |
| 7:00 pm - 8:00 pm |
Keynote Speaker:
Dr. Phil Robbins
(Boston University School of Dental Medicine)
"The Past, the Present... and All That" |
| 8:00 pm - 10:00 pm |
Welcome Reception |
Thursday, November 12, 1998
|
| 8:30 am - 10:00 am |
Title: Glycan Biosynthesis I
Chair: Pamela Stanley |
|
Three talks; each 20 min plus 5 min for questions:-
Tommy Nilsson (EMBL, Heidelberg, Germany)
"Targeting of glycosylation enzymes to the Golgi apparatus"
Carlos Hirschberg (Boston University Goldman School of Dental Medicine)
"Novel Regulation of posttranslational modifications in the Golgi apparatus of Mammals and Yeast"
Rita Gerardy-Schan (Medizinische Hochschule, Hannover, Germany)
"The CMP-sialic acid transporter: membrane topology and primary sequence elements of functional relevance" |
|
Plus three 5 min talks chosen from abstracts; no questions:-
Joseph T.Y. Lau Dept. of Molecular Biology, Roswell Park Cancer Institute, 666 Elm Street, Buffalo, NY 14263
"Functional analysis of the hepatic-specific promoter of ST6Gal-1 by targeted mutagenesis"
Christopher M. West Dept. of Anatomy & Cell Biology, University of Florida College of Medicine, Gainesville, FL 32610-0235 USA
"Evidence that a Protein Involved in Ubiquitination is Modified by a Novel Cytoplasmic Glycosylation Pathway"
Daniel J. Moloney Department of Biochemistry and Cell Biology, SUNY-Stony Brook.
"O-linked Carbohydrate Modifications on the Epidermal Growth Factor-like Modules of Mammalian Notch" |
| 10:00 am - 10:30 am |
Break |
| 10:30 am - 12:30 pm |
Title: Microbial Glycobiology
Chair: Sam Turco |
|
Four talks; each 20 min plus 5 min for questions:-
Patricia Spear (Northwestern University)
"Cell surface glycosaminoglycans and protein receptors as determinants of herpes simplex virus entry"
Paul DeAngelis (University of Oklahoma)
"Unexpected hyaluronan synthases from virus PBCV-1 and Pasteurella bacteria"
Christian Raetz (Duke University)
"Assembly and function of lipopolysaccharides in Gram-negative bacteria"
Daniel Stein (University of Maryland)
"Genetic basis of lipooligosaccharide biosynthesis and variation in Neisseria gonorrhoeae" |
|
Plus three 5 min talks chosen from abstracts; no questions:-
Alvaro Acosta-Serrano Dept. of Biological Chemistry, Johns Hopkins University
"The structural basis of ConA-resistance in Trypanosoma brucei glycosylation mutants"
Todeschini, A.R. Instituto de Microbiologia, Universidade Federal do Rio de Janeiro, 21944-970 Cidade Universitaria, Rio de Janeiro, Brazil
"Trans-sialidase from Trypanosoma cruzi catalyzes sialoside hydrolysis with retention of configuration"
Girija Ramakrishnan Departments of Medicine, University of Virginia, Charlottesville, VA
"Phenotypic analysis of Entamoeba histolytica using dominant-negative mutants of the adherence lectin" |
| 12:30 pm - 2:30 pm |
Lunch break/informal poster viewing - poster author need not be present |
| 2:30 pm - 4:00 pm |
Title: Invertebrate Glycobiology
Chair: Richard Cummings |
|
Three talks; 20 min and 5 min for questions:-
Tory Herman (Massachusetts Institute of Technology)
"Three proteins involved in C. elegans vulval invagination are similar
to components of a glycosylation pathway"
Xinhua Lin (Harvard University)
"Roles of heparin sulfate proteoglycans in Wingless/Wnt and FGF signaling in Drosophila"
Keith Nehrke(University of Rochester)
"The initial step in mucin O-glycosylation is conserved from worms to man" |
|
Plus three talks from abstracts; 5 min each; no questions:-
Neta Dean Department of Biochemistry and Cell Biology, State University of New York, Stony Brook, New York 11794-5215
"Regulation of Nucleotide Sugar Transport in Yeast"
Charles E Warren Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada.
"The C. elegans gene, gly-2, is an orthologue of mammalian N-Acetylglucosaminyltransferase V"
E. T. A. Marques Jr. The Johns Hopkins University School of Medicine; Department of Pharmacology and Molecular Sciences.
"Molecular characterization of a fucosyltransferase type VII encoded by Schistosoma mansoni." |
| 4:00 pm - 6:00 pm |
Poster Session 1 and Exhibits - attended by author(s) during this time
Refreshments |
| 5:30 pm - 6:30 pm |
Cash bar in Poster area |
7:30 pm - 8:30pm
(questions until 9:00 pm) |
Mark S. Boguski (Senior Investigator,Computational Biology Branch,National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health)
"Closing the gap between sequence and function: the frontier of computational biology and functional genomics" |
9:00 pm - 9:15 pm
(questions until 9:30 pm) |
Louis N Gastinel (AFMB, CNRS-UPR 9039, Marseille, France)
"Crystal Structure of the Bovine b4Gal-T1 Catalytic Domain" |
Friday, November 13, 1998
|
| 8:30 am - 10:00 am |
Title: Glycan Biosynthesis II
Chair: Mark Lehrman |
|
Three talks; each 20 min plus 5 min for questions:-
Carolyn Machamer (Johns Hopkins University)
"Glycolipid synthesis and targeting of resident Golgi proteins"
Charles Waechter (University of Kentucky)
"Use of Water-Soluble Analogues to Invesitigate the Role of ER Proteins in the Transbilayer Movement of Glucosylphosphoryldolichol"
Sean Munro (MRC, Cambridge, UK)
"Complexes of glycosyltransferases in the yeast Golgi" |
|
Plus three 5 min talks chosen from abstracts; no questions:-
Hiromu Takematsu Glycobiology Program, University of California San Diego, La Jolla, CA 92093-0687
"The Lysosomal Sialic Acid 9-O-acetylesterase Gene Also Encodes a Cytosolic Form"
Li Shao Department of Biochemistry and Cell Biology, SUNY-Stony Brook
"Identification and Initial Characterization of a UDP-Glucose: Polypeptide Glucosyltransferase Activity from Chinese Hamster Ovary Cells"
Neng Chen Dept. of Molecular Biology, Roswell Park Cancer Institute, 666 Elm Street, Buffalo NY 14263
"Functional analysis of ST3Gal-2 by targeted mutagenesis" |
| 10:00 am - 10:30 am |
Break |
| 10:30 am - 12:30 pm |
Title: Glycobiology and the Immune System
Chair: Jeff Esko |
|
Four talks; each 20 min plus 5 min for questions:-
Daniel Chui (University of California at San Diego)
"Immune dysfunction in mice lacking ST6Gal"
Alan Ezekowitz (Harvard University)
"Pattern recognition in first line host defense"
Sebastian Joyce (Penn State University)
"The role of cellular glycolipids in CD1 structure and function"
Mark Siegelman (University of Texas Southwestern)
"CD44 interactions with hyaluronate in immunity and autoimmunity" |
|
Plus three 5 min talks chosen from abstracts; no questions:-
Glennda Smithson Howard Hughes Medical Institute, University of Michigan, 1150 West Medical Center Drive, Ann Arbor MI 48109-0650.
"Multiple genotype specific defects in the contact hypersensitivity response of fucosyltransferase deficient mice"
Stefan Hemmerich Roche Bioscience, Palo Alto, CA, USA.
"Cloning and Functional Characterization of a Human Glycosyl Sulfotransferase, that is Highly Restricted to High Endothelial Venules and Confers Expression of the L-Selectin Recognition Epitope 6-Sulfo Sialyl Lewis X."
Toshisuke Kawasaki Faculty of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan
"Anti-tumor Activity of Mannan-binding Protein through MBP Dependent Cell Mediated Cytotoxicity (MDCC)" |
| 12:30 pm - 2:30 pm |
Lunch break/informal poster viewing - poster author need not be present
Society Board Meeting |
| 2:30 pm - 4:00 pm |
Title: Analytical and Structural Approaches in Glycobiology
Chair: Robert Trimble |
|
Three talks; 20 min and 5 min for questions:-
Vern Reinhold (University of New Hampshire)
"Ion trapping MS and understanding carbohydrate structural detail"
Frank Barry (Osiris Therapeutics, Baltimore, MD)
"Changes in glycosylation of cartilage matrix molecules during development and disease"
Richard Quarles (National Institute of Neurological Disorders and Stroke, NIH)
"Oligosaccharides of glycoproteins in the formation and maintenance of myelinated axons" |
|
Plus three talks from abstracts; 5 min each; no questions:-
Kalyan R. Anumula Bioanalytical Sciences Dept., UW2960, Research and Development, SmithKline Beecham Pharmaceuticals, 709 Swedeland Rd., King of Prussia, PA 19406, USA
"Evaluation Of Various Fluorescent Tags For Oligosaccharide Characterization: A Comparative Study With Anthranilic Acid"
Nelly Viseux Mass Spectrometry Resource, Boston University School of Medicine, Boston, MA 02118
"Structural Characterization of Permethylated Oligosaccharides by Matrix-Assisted Laser Desorption/Ionization Post-Source Decay Mass Spectrometry"
Paul A. Haynes Department of Molecular Biotechnology, School of Medicine, Box 357730, University of Washington, Seattle, WA 98195-7730
"DETECTION AND IDENTIFICATION OF O-GlcNAc MODIFIED PROTEINS FROM WHOLE CELL LYSATES" |
| 4:00 pm - 4:30 pm |
Break |
|
|
| Genzyme & Karl Meyer Award Ceremonies/Lectures Chair: John Lowe |
4:30pm to 5:00pm
Genzyme Award Lecture
Tory Herman (HHMI, UCLA) |
5:00 pm - 6:00 pm
Karl Meyer Award
Harry Schachter (Hospital for Sick Children, Toronto, Canada)
"The Joys of Hex(NAc)" | |
| 6:00 pm - 7:00 pm |
Cash Bar, Baltimore Foyer |
| 7:30 pm - 9:30 pm |
Banquet |
Saturday, November 14, 1998
|
| 8:30 am - 10:00 am |
Title: Glycan Biosynthesis III
Chair: Minoru Fukuda |
|
Three talks; each 20 min plus 5 min for questions:-
Jeff Esko (University of California at San Diego)
"A glucuronosyltransferase that assembles the glycosaminoglycan linkage region and HNK-1"
Lena Kjellen (Swedish Univ of Ag Sciences, Stockholm)
"Phenotypic characterization of mice lacking genes coding for DASTs, heparan sulfate glucosaminyl N-deacetylase/N-sulfotransferases"
Henrik Clausen (University of Copenhagen)
"Characterization of galactosyltransferase gene families" |
|
Plus three 5 min talks chosen from abstracts; no questions:-
Robert D.Rosenberg Massachusetts Institute of Technology, Cambridge, MA 02139
"New Paradigm for the Synthesis of Specific Sequences of Heparan Sulfates"
Edgar Ong Glycobiology Program, La Jolla Cancer Research Center, The Burnham Institute, La Jolla, CA 92037
"Biosynthesis of the HNK-1 glycans on O-linked oligosaccharides attached to the neural cell adhesion molecule (NCAM) and their roles in adhesion to laminin: The requirement for core2 b-1,6-N-acetylglucosaminyltransferase and the muscle specific domain in NCAM"
Kelly G. Ten Hagen Center for Oral Biology, Rochester Institute of Biomedical Sciences, University of Rochester, 601 Elmwood Avenue, Box 611, Rochester, NY, 14642
"Cloning, Expression and Characterization of a Member of the UDP-N-Acetyl-D-Galactosamine:polypeptide N-acetylgalactosaminyltransferase Family Which Displays Glycopeptide N-acetylgalactosaminyltransferase Activity" |
| 10:00 am - 10:30 am |
Break |
| 10:30 am - 12:00 pm |
Title: Glycans and Medical Pathophysiology
Chair: Harry Schachter |
|
Three talks; each 20 min plus 5 min for questions:-
Karen Mohlke (University of Michigan)
"Altered expression of an N-acetylgalactosamine transferase is a major modifier of murine plasma von Willebrand factor levels"
Marcus Aebi (Mikrobiologisches Institut, ETH, Zurich)
"A novel carbohydrate-deficient glycoprotein syndrome characterized by a deficiency in glucosylation of the dolichol-linked oligosaccharide"
Jacques Baenziger (Washington University St. Louis)
"The Man/GalNAc-4-sulfate receptor: A receptor with many faces" |
|
Plus three 5 min talks chosen from abstracts; no questions:-
Stephanie GRUENEWALD Laboratory for Molecular Diagnosis, Center for Human Genetics, University of Leuven, Leuven, Belgium.
"The phosphomannomutases in human and mouse: gene structure, expression pattern and role in disease."
P. Stanley Dept. Cell Biology, Albert Einstein College Medicine, New York, NY, 10461..
"A Mouse Model of Sanfilippo Syndrome."
M.W. Long Department of Pediatrics, University of Michigan, Ann Arbor, MI.
"a(1,3)-FUCOSYLTRANSFERASES PLAY AN ESSENTIAL ROLE IN THE MAINTENANCE OF HEMATOPOIETIC HOMEOSTASIS" |
| 12:00 pm - 1:00 pm |
Lunch break/informal poster viewing - poster author need not be present |
| 1:00 pm - 2:30 pm |
Title: Glycan-Protein Interactions I
Chair: Vern Reinhold |
|
Three talks; each 20 min plus 5 min for questions:-
Lesley Ellies (University of California at San Diego)
"The function of core 2 O-glycans in selectin ligand formation and leukocyte trafficking"
Kevin Rice (University of Michigan)
"Multivalent interaction of sialyl Lewis x N-linked oligosaccharides with selectins in vivo"
Joel Shaper (Johns Hopkins University)
"Murine sperm-zona binding: an a3-fucosyl residue is required for the assembly of a high affinity sperm-binding ligand" |
|
Plus two 5 min talks chosen from abstracts; no questions:-
T. Shantha Raju Analytical Chemistry, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA
"Affinity of O-Glycans for Jacalin-Agarose in the Presence of N-Linked Oligosaccharides"
Jennifer M. Burns Division of Basic Science and Vaccine Research, Institute of Human Virology, University of Maryland School of Medicine
"RANTES Suppresses HIV-1 Infection But Does Not Activate Cognate Receptors after Binding to Soluble Glycosaminoglycans" |
| 2:30 pm - 3:00 pm |
Break |
| 3:00 - 4:00 pm |
Title: Glycan-Protein Interactions II |
|
Special Lecture:
Dr. Wayne Yokoyama
(Wash. Univ - St. Louis)
"C-type lectin-like natural killer cell receptors" |
| 4:00 pm - 6:00 pm |
Poster Session 2 and Exhibits - attended by author(s) during this time
Refreshments |
| 5:30 pm |
Farewell Champagne Toast |