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| WEDNESDAY, NOVEMBER 8, 2000 |
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| 3:00-7:30 pm |
REGISTRATION |
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| Time |
7:30pm: KEYNOTE ADDRESS |
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| 7:30pm |
Introductory Remarks
Sam Turco, President |
| 7:40pm |
Keynote Address
Jerry Silbert, Chair |
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Lectins - from obscurity into center stage.
Nathan Sharon, Weizmann Institute, Israel |
| 8:30-10:30 pm |
Welcome Reception |
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| THURSDAY, NOVEMBER 9, 2000 |
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| Time |
8:30am: CARBOHYDRATE-BINDING PROTEINS
Vernon Reinhold, Chair |
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| 8:30am |
Comparative Studies of the Carbohydrate Binding and Physical Properties of Galectin-1 and Galectin-3
Fred Brewer, Albert Einstein College of Medicine |
| 8:55am |
LNP: A Nod Factor-Binding Protein from Legume Roots is Involved in the Initiation of the Rhizobium-Legume Symbiosis
Marilynn Etzler, University of California, Davis |
| 9:20am |
RECOGNITION OF MISFOLDED CONFORMERS BY THE UDP-GLC:GLYCOPROTEIN GLUCOSYLTRANSFERASE
Armando Parodi, University of San Martin, Argentina |
| 9:45am |
A Novel Sialoside Probe for Detecting Unmasked CD22 on Murine B Cells
Brian E. Collins, The Scripps Research Institute |
| 9:50am |
GALECTIN-10 IS NOT A DUAL-FUNCTION LECTIN WITH LYSOPHOSPHOLIPASE ACTIVITY, BUT BINDS A LYSOPHOSPHOLIPASE INHIBITOR IN A STRUCTURALLY NOVEL FASHION
Steven J. Ackerman, Ph.D., University of Illinois at Chicago |
| 9:55am |
How the Man/GalNAc-4-SO4-receptor discriminates different sulfated structures.
Daniel S. Roseman, Washington University School of Medicine |
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| 10:00-10:30 am |
BREAK (POSTERS, EXHIBITS) |
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| Time |
10:30am: GLYCOCONJUGATE ASSEMBLY I
Tamara Doering, Chair |
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| 10:30am |
Peptide:N-glycanase Interact with RAD23 protein
William Lennarz, SUNY-Stony Brook |
| 10:55am |
The General Role Of The Lec35 Gene In Monosaccharide-P-Dolichol Dependent Glycosyltransferase Reactions In Hamster Cells
Mark Lehrman, UT-Southwestern Medical Center |
| 11:20am |
Structure and function of Class 1 a-mannosidases in glycoprotein maturation and quality control
Kelley Moremen, University of Georgia |
| 11:45am |
a2,8-Polysialylation of NCAM and the Polysialyltransferases
Karen Colley, University of Illinois College of Medicine |
| 12:10pm |
ALLOSTERIC REGULATION OF OLIGOSACCHARIDE SUBSTRATE BINDING TO THE YEAST OLIGOSACCHARYLTRANSFERASE
Denise Karaoglu, University of Massachusetts Medical School |
| 12:15pm |
Metabolization of N-acetylmannosamine and N-propanoylmannosamine to sialic acids in cells lacking UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase
Stephan Hinderlich, Free University of Berlin |
| 12:20pm |
Investigation of the binding and substrate specificity of the CMP-sialic acid transporter of the Golgi apparatus
Molly M. Slazas, University of Colorado |
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| 2:00-4:00 pm |
POSTER SESSION |
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| Time |
4:00pm: GLYCOCONJUGATE ASSEMBLY II
William Young, Chair |
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| 4:00pm |
Using in vitro Phosphorylation to Prepare Highly Phosphorylated Lysosomal Enzymes for Therapy of Lysosomal Storage Diseases
William M. Canfield, University of Oklahoma & Novazyme Pharmaceuticals, Inc |
| 4:25pm |
Biological Consequences of Inactivating the Mgat3 Gene that Encodes GlcNAc-TIII.
Pamela Stanley, Albert Einstein College Medicine |
| 4:50pm |
MODULATION OF SIGNAL TRANSDUCTION BY DIFFERENTIAL RECEPTOR GLYCOSYLATION: THE ROLE OF O-LINKED FUCOSE IN NOTCH SIGNALING
Bob Haltiwanger, SUNY-Stony Brook |
| 5:15pm |
Four isozymes of GlcNAc N-deacetylase/N-sulfotransferases initiate the modification of heparan sulfate
Jeff Esko, University of California, San Diego |
| 5:40pm |
CORNEAL EPITHELIAL CELL-CELL ADHESION CONTACT-REGULATED EXPRESSION OF a1-3 FUCOSYLTRANSFERASES
N. Panjwani, Tufts University |
| 5:45pm |
3-OST-1 Deficient Mice Lack an Obvious Procoagulant Phenotype.
Nicholas W. Shworak, Harvard Medical School/Beth Israel Deconess Medical Center |
| 5:50pm |
Convergent Evolution of a non-Golgi alpha1,2-Fucosyl-transferase that Modifies Skp1 in the Cytoplasm of Dictyostelium
Christopher M. West, University of Florida |
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| FRIDAY, NOVEMBER 10, 2000 |
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| Time |
8:30am: GLYCOBIOLOGY AND GENETICS
Marcus Aebi, Chair |
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| 8:30am |
A novel disorder in a newborn caused by defective biosynthesis of N-linked oligosaccharides due to glucosidase I deficiency
Hans Vliegenthart, Bijvoet Center, Utrecht University |
| 8:55am |
Human and mouse homologs of the Xenopus oocyte cortical granule lectin XL35
Mike Pierce, University of Georgia |
| 9:20am |
CHARACTERIZATION OF THE HYALURONAN RECEPTOR FOR ENDOCYTOSIS (HARE).
Paul Weigel, University of Oklahoma Health Sciences Center |
| 9:45am |
The Biosynthetic Pathway for Generating the Antithrombin Binding Site on Heparan Sulfate
Lijuan Zhang, MIT & BIDMC |
| 9:50am |
Chromosomal Localization and Genomic Organization for the Galactose/N-Acetylgalactosamine/N-Acetylglucosamine 6-O-Sulfotransferase Gene Family
Stefan Hemmerich, Roche Bioscience, Palo Alto |
| 9:55am |
DEFECTIVE HEMATOPOIETIC STEM CELL (HSC) HOMING/ENGRAFTMENT IN FUCOSYLTRANSFERASE-NULL MICE.
Sujata Kale, University of Michigan |
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| 10:00-10:30 am |
BREAK (POSTERS, EXHIBITS) |
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| Time |
10:30am: GLYCAN FUNCTIONS
Robert Trimble, Chair |
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| 10:30am |
How terminal GalNAc-4-SO4 and the Man/GalNAc-4-SO4-receptor contribute to activation of the LH receptor in vivo.
Jacques Baenziger, Washington University School of Medicine |
| 10:55am |
Ganglioside functions in nervous system physiology and pathology
Ron Schnaar, The Johns Hopkins School of Medicine |
| 11:20am |
Platelets, P-selectin, Carcinoma Mucins, Metastasis and Heparin: Mechanistic Connections with Therapeutic Potential
Ajit Varki, University of California, San Diego |
| 11:45am |
Involvement of the Asn-420-linked sugar chain in controllable activation of human epidermal growth factor receptor
Naoyuki Taniguchi, Osaka University Medical School, Japan |
| 12:10pm |
A role for O-GlcNAc? The essential splicing protein ASF/SF2 is O-GlcNAcylated only in the cytoplasm, where it appears to play a role in mRNA transport/translation.
Natasha E. Zachara, Johns Hopkins University Medical School |
| 12:15pm |
A novel anionic modification of N-glycans on mammalian endothelial cells is recognized by activated neutrophils and modulates acute inflammatory responses
Geetha Srikrishna, The Burnham Institute, La Jolla, California |
| 12:20pm |
PROTECTION OF PIG KIDNEY CELLS FROM HUMAN SERUM CYTOTOXICITY BY SYNTHETIC ALPHA-GAL EPITOPE POLYMERS
Xi Chen, Wayne State University, Detroit, MI |
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| 12:30pm |
Board of Directors Meeting - Hancock Room |
| 2:00-4:00 pm |
POSTER SESSION |
| 4:00-5:00 pm |
Society business meeting |
| 5:00-6:00 pm |
Karl Meyer Award Lecture
Sharon Krag, Chair
Phillips W Robbins, Boston University, Boston, MA |
| 7:30 pm |
Conference Banquet |
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| SATURDAY, NOVEMBER 11, 2000 |
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| Time |
8:30am: GLYCOBIOLOGY AND SIGNAL TRANSDUCTION
Richard Cummings, Chair |
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| 8:30am |
Variation in components and function of glycosignaling domain, and factors affecting them
Sen Hakomori, Pacific Northwest Res Inst |
| 8:55am |
Glycosylation controls T cell death induced by galectin-1
Linda Baum, UCLA School of Medicine |
| 9:20am |
Dynamic Interplay Between ß-O-GlcNAc & O-Phosphate on Nuclear and Cytosolic Proteins.
Jerry Hart, Johns Hopkins Univ. School of Medicine |
| 9:45am |
A functionally distinct heparan sulfate chain attached to syndecan 2 mediates early left-right development in Xenopus
Kenneth L. Kramer, University of Utah |
| 9:50am |
Myelin-associated glycoprotein is selectively and progressively down-regulated in the central and peripheral nervous systems of complex ganglioside knockout mice
Ji Sun, Johns Hopkins School of Medicine |
| 9:55am |
THE ROLE OF GALECTIN-3 IN CORNEAL EPITHELIAL CELL MIGRATION AND WOUND HEALING
Z. Cao, Tufts University |
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| 10:00-10:30 am |
BREAK (POSTERS, EXHIBITS) |
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| Time |
10:30am: GLYCOBIOLOGY AND LOWER ORGANISMS
Ralph Schwarz, Chair |
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| 10:30am |
Regulated Covalent Modifications of Lipid A Required for Polymyxin Resistance in Gram-negative Bacteria
Chris Raetz, Duke University Medical Center |
| 10:55am |
The first mannosyltransferase in GPI anchor biosynthesis from mammalian cells, yeast and protozoan parasites.
Taroh Kinoshita, Osaka University |
| 11:20am |
The bittersweet interface of parasite and host: Lectin-carbohydrate interactions during human invasion by the parasite Entamoeba histolytica
Bill Petri, University of Virginia |
| 11:45am |
Ultra-high sensitivity MS studies of glycopolymers from lower organisms
Anne Dell, Imperial College |
| 12:10pm |
Structural Characterization of Glycosylphosphatidylinositol Anchors of Plasmodium falciparum
Channe D. Gowda, Georgetown University Medical Center |
| 12:15pm |
Purification and Characterization of 1-Deoxyxylulose 5-Phosphate Synthase from Mycobacterium tuberculosis.
Ann Marie Bailey, Colorado State University |
| 12:20pm |
Cloning and characterization of GPI-1 homologue from Plasmodium falciparum
Hosam SHAMS-ELDIN, MZH, University of Marburg |
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| 2:00-4:00 pm |
POSTER SESSION |
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| Time |
4:00pm: GLYCOBIOLOGY AND DISEASE
Annette Herscovics, Chair |
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| 4:00pm |
Functions of Glycosphingolipids at Membrane Surfaces - Pathogenesis of Neurodegenerative and Dermal Genetic Disorders
Konrad Sandhoff, Universität Bonn, Germany |
| 4:25pm |
CYSTIC FIBROSIS PULMONARY DISEASE: POTENTIAL GENE AND GLYCAN THERAPY
Tom Scanlin, Cystic Fibrosis Center and Department of Pediatrics, University of Pennsylvania School of Medicine and The Children's Hospital of Philadelphia |
| 4:50pm |
Fetuin / a2-HS-Glycoprotein is a TGF-b Binding Glycoprotein that Regulates Bone Growth and Remodeling
James Dennis, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto |
| 5:15pm |
Fabry disease: In vitro inhibition and intracellular enhancement of lysosomal a-galactosidase A activity in Fabry lymphoblasts by 1-deoxygalactonojirimycin and its derivatives.
Jian-Qiang Fan, Mount Sinai School of Medicine |
| 5:20pm |
Antibody Development to a Peptide Mimic of T antigen
Kate Rittenhouse-Olson, State University of New York at Buffalo |
| 5:25pm |
Expression of N-Glycolyl-neuraminic acid in Normal, Fetal and Malignant Human Tissues.
Pam Tangvoranuntakul, University of California, San Diego |
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| 5:45 pm |
Farewell Reception |
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